奥曲肽治疗肝硬化合并上消化道出血的临床疗效观察  

Clinical Observation of Octreotide in the Treatment of Cirrhosis with upper Gastrointestinal Hemorrhage

作　　者：张红丹 ZHANG Hongdan(Fuxin Second People's Hospital of Liaoning Province(Fuxin Obstetrics and Gynecology Hospital),Fuxin 123000,China)

机构地区：[1]辽宁省阜新市第二人民医院(阜新市妇产医院),辽宁阜新123000

出　　处：《中国医药指南》2021年第20期48-49,共2页Guide of China Medicine

摘　　要：目的关于奥曲肽对肝硬化合并上消化道出血进行治疗的临床效果探究。方法将2018年4月至2019年4月到我院治疗的72例肝硬化合并上消化道出血患者随机分为观察组和对照组,每组36例。对两组患者配合常规的治疗,在此基础上对观察组患者配合奥曲肽治疗,对照组患者应用泮托拉唑进行治疗,比较两组患者不同治疗后的效果。结果观察组患者的病情控制有效率为88.89%(32/36),对照组为69.44%(25/36),P<0.05;观察组治疗48 h后再出血率为3.13%(1/32),对照组为32.00%(8/25),P<0.05;观察组并发症发生率为8.33%(3/36),对照组并发症发生率为30.56%(11/36),P<0.05;观察组患者的止血时间为(19.24±3.12)h,对照组为(31.44±4.27)h,P<0.05,存在统计学差异性。结论对肝硬化合并上消化道出血的患者以奥曲肽实施治疗可有效的控制患者出血再发生率,减轻并发症对患者产生的影响,缩短止血时间,是一种理想的用药方法。Objective To investigate the clinical effect of octreotide in the treatment of cirrhosis with upper gastrointestinal hemorrhage.Methods A total of 72 patients with liver cirrhosis and upper gastrointestinal bleeding who came to our hospital for treatment from April 2018 to April 2019 were randomly divided into observation group and control group,with 36 cases in both groups.The two groups of patients were combined with conventional treatment.On this basis,the observation group was combined with octreotide treatment,and the control group was treated with pantoprazole.The effects of the two groups of patients after different treatments were compared.Results The effective rate of disease control in the observation group was 88.89%(32/36),69.44%(25/36)in the control group,P<0.05.The rebleed rate was 3.13%(1/32)after 48 hours in the observation group,the control group was 32.00%(8/25),P<0.05;the complication rate in the observation group was 8.33%(3/36),and the complication rate in the control group was 30.56%(11/36),P<0.05.The hemostasis time of the observation group was(19.24±3.12)h,and that of the control group was(31.44±4.27)h,P<0.05,and there was statistical difference.Conclusion Octreotide treatment for patients with liver cirrhosis and upper gastrointestinal bleeding can effectively control the recurrence rate of bleeding,reduce the impact of complications on patients,and shorten the time of hemostasis.It is an ideal medication method.

关 键 词：肝硬化 上消化道出血 奥曲肽 

分 类 号：R575.2[医药卫生—消化系统] R573.2[医药卫生—内科学]