SARS-CoV-2 with concurrent coccidioidomycosis complicated by refractory pneumothorax in a Hispanic male: A case report and literature review  

作　　者：Joscilin Mathew Sundar V Cherukuri Fatma Dihowm 

机构地区：[1]Department of Internal Medicine,Texas Tech University Health Sciences Center El Paso,El Paso,TX 79905,United States

出　　处：《World Journal of Respirology》2021年第1期1-11,共11页世界呼吸病学杂志

摘　　要：BACKGROUND The incidence of secondary coinfections particularly fungal infections among severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is not well described.Little is known of the complications that could be encountered in such conditions.CASE SUMMARY A 50-year-old Hispanic male who was a prior smoker presented with shortness of breath.He was diagnosed with SARS-CoV-2.He improved and was discharged with home oxygen.A month later,he presented with sudden onset cough and shortness of breath.Chest X-ray showed development of right-sided tension pneumothorax,right pleural effusion and an air-filled cystic structure.Computed tomography thorax showed findings suggestive of pulmonary coccidioidomycosis.Coccidioides antigen was positive,and fluconazole was initiated.For pneumothorax,a pigtail catheter was placed.The pigtail chest tube was later switched to water seal,unfortunately,the pneumothorax re-expanded.Another attempt to transition chest tube to water seal was unsuccessful.Pigtail chest tube was then swapped to 32-Fr chest tube and chemical pleurodesis was performed.This was later transitioned successfully to water seal and finally removed.He was discharged on a four-week oral course of fluconazole 400 mg and was to follow up closely as an outpatient for continued monitoring.CONCLUSION Pneumothorax is associated with a worse prognosis,especially with comorbidities such as diabetes,immunosuppression and malignancy.Suspicion for concomitant fungal infection in such patients should be high and would necessitate further investigation.

关 键 词：SARS-CoV-2 COVID-19 COCCIDIOIDOMYCOSIS CO-INFECTION Fungal infection Tension pneumothorax Refractory pneumothorax Case report Literature review 

分 类 号：R73[医药卫生—肿瘤]