慢性脑小血管病影像标志物对心源性脑栓塞患者预后的影响  

Influence of neuroimaging markers of chronic cerebral small vessel disease on prognosis of patients with cardioembolic stroke

作　　者：郭义坤 张敏 王倩 陈卓友 董贯忠 姚畑 徐运[2] Guo Yikun;Zhang Min;Wang Qian;Chen Zhuoyou;Dong Guanzhong;Yao Tian;Xu Yun(Department of Neurology,the Affiliated Changzhou No.2 People′s Hospital of Nanjing Medical University,Changzhou 213000,China;Department of Neurology,Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University,Nanjing 210008,China)

机构地区：[1]南京医科大学附属常州第二人民医院神经内科,常州213000 [2]南京医科大学附属南京鼓楼医院神经内科,南京210008

出　　处：《中华医学杂志》2021年第29期2333-2336,共4页National Medical Journal of China

基　　金：江苏省科技厅医学重点项目(BE2020620)。

摘　　要：回顾性分析于2014年6月至2019年9月在常州市第二人民医院住院治疗的初次心源性脑栓塞患者资料189例,评估患者的慢性脑小血管病神经影像学标志物,计算其总负荷评分(0~3分)。发病90 d时,65例患者预后不良。回归分析显示,慢性脑小血管病神经影像学标志物总负荷评分是预后不良的独立危险因素(OR=1.754,95%CI:1.137~2.707,P=0.011)。Data of 189 patients with first-ever cardioembolic stroke(CES)hospitalized in the Second People′s Hospital of Changzhou from June 2014 to September 2019 were retrospectively analyzed.The neuoimaging markers of chronic small vessel disease(cSVDm)were evaluated and their total burden(0-3 points)was calculated.At 90 d after onset,65 patients had poor prognosis.Regression analysis showed that the total cSVDm burden score was an independent riskfactor for the poor prognosis(OR=1.754,95%CI:1.137-2.707,P=0.011).

关 键 词：脑小血管病 心源性脑栓塞 神经影像学 标志物 预后 

分 类 号：R743.3[医药卫生—神经病学与精神病学]