Identification of a serum three-microRNA signature for cervical cancer diagnosis  

作　　者：Min-Min Cao Qing-Xie Liu Xuan Zou Xing-Chen Fan Cheng Liu Shi-Yu Zhang Tong-Shan Wang Chun-Yu Li Cheng Zhang Xiang-Nan Geng Ping Liu Wei Zhu 

机构地区：[1]Department of Oncology,First Affiliated Hospital of Nanjing Medical University,Nanjing,Jiangsu 210029,China [2]Department of Oncology,Fudan University Shanghai Cancer Center,Shanghai 200032,China [3]Department of Gastroenterology,First Affiliated Hospital of Nanjing Medical University,Nanjing,Jiangsu 210029,China [4]Department of Intensive Care Unit,First Affiliated Hospital of Nanjing Medical University,Nanjing,Jiangsu 210029,China [5]Department of Science and Technology,First Affiliated Hospital of Nanjing Medical University,Nanjing,Jiangsu 210029,China [6]Department of Clinical Engineer,First Affiliated Hospital of Nanjing Medical University,Nanjing,Jiangsu 210029,China

出　　处：《Chinese Medical Journal》2021年第14期1756-1758,共3页中华医学杂志（英文版）

基　　金：the National Natural Science Foundation of China(Nos.81672400 and 81672788).

摘　　要：To the Editor:Cervical cancer(CC)is one of the leading causes of cancer deaths in women around the world.[1]In clinical practice,screening methods such as human papillomavirus testing and cytology-based detection have the disadvantages of having a high false rate,being hysteretic or ineffective.[2]Novel non-invasive biomarkers that can help diagnose CC with higher specificity and sensitivity are in great demand.MicroRNA(miRNA)is a type of non-coding small RNA of 18 to 25 nucleotides in length.Circulating miRNAs show the great potential of being cancer biomarkers for the stable existence in peripheral serum or plasma.[3]In this study,we performed a four-stage experiment using a total of 108 CC and 108 normal control(NC)serum samples to explore the diagnostic potential of serum miRNAs in CC.The schematic diagram of the experimental procedure was shown in Supplementary Figure 1,http://links.lww.com/CM9/A429.

关 键 词：SPECIFICITY FIGURE false 

分 类 号：R737.33[医药卫生—肿瘤]