神经丝蛋白轻链与帕金森综合征相关研究进展  

Research progress of neurofilament light chain in the parkinsonism

作　　者：肖一 张灵语 欧汝威 李春雨[1] 商慧芳[1] Xiao Yi;Zhang Lingyu;Ou Ruwei;Li Chunyu;Shang Huifang(Department of Neurology,West China Hospital,Sichuan University,Chengdu 610041,China)

机构地区：[1]四川大学华西医院神经内科,成都610041

出　　处：《中华神经科杂志》2021年第8期843-847,共5页Chinese Journal of Neurology

基　　金：国家自然科学基金(81871000);四川大学华西医院学科卓越发展“1·3·5”工程项目(ZYJC18038)。

摘　　要：神经丝蛋白轻链(NfL)是一种轴突损伤的敏感标志物,在多种神经系统疾病中升高。帕金森综合征是一类以肌强直、运动迟缓等为主要特征的临床症候群,包括帕金森病和帕金森叠加综合征(PPS)等变性疾病。早期鉴别诊断帕金森病和PPS是神经科的难点。近年研究表明NfL可能是辅助鉴别帕金森病和PPS的潜在生物标志物。文中综述了脑脊液和血液中的NfL在帕金森病和PPS中的研究进展及未来可能的研究方向。Neurofilament light chain(NfL),a sensitive biomarker of axonal damage,was found increasing in several neurological diseases.Parkinsonism is a group of clinical syndromes characterized by cardinal symptoms of bradykinesia,rigidity,and tremor,including Parkinson′s disease(PD)and parkinsonism plus syndrome(PPS).It is difficult in the diagnosis and differential diagnosis of PD and PPS,especially in the early stage.Evidence suggests that NfL in the cerebrospinal fluid and blood is a promising biomarker for the differential diagnosis of PD and PPS.This article reviewed and summarized the research progress of value of NfL in PD and PPS,and proposed future research directions.

关 键 词：帕金森病 诊断 预后 神经丝蛋白轻链 帕金森叠加综合征 

分 类 号：R742.5[医药卫生—神经病学与精神病学]