Retinal microglial activation in glaucoma:evolution over time in a unilateral ocular hypertension model  

作　　者：JoséA.Fernández-Albarral Ana I.Ramírez Rosa de Hoz Juan J.Salazar 

机构地区：[1]Instituto de Investigaciones Oftalmológicas Ramón Castroviejo,Universidad Complutense de Madrid,Madrid,Spain [2]Facultad deÓptica y Optometría,Departamento de Inmunología,Oftalmología y ORL,Universidad Complutense de Madrid,Madrid,Spain

出　　处：《Neural Regeneration Research》2022年第4期797-799,共3页中国神经再生研究（英文版）

基　　金：supported by the Ophthalmological Network OFTARED(RD16/0008/0005),of the Institute of Health of CarlosⅢof the Spanish Ministry of Economy(to AIR,RDH,and JJS);Santander-Complutense University of Madrid Research Projects(PR75/18-21560)(to AIR,RNH,and JJS);supported by a Predoctoral Fellowship(FPU17/01023)from the Spanish Ministry of Science,Innovation,and Universities。

摘　　要：Glaucoma is a neurodegenerative chronic pathology,characterized by the loss of retinal ganglion cells(RGC),which leads to an irreversible vision field loss.The increased intraocular pressure(IOP)constitutes its main risk factor.Nowadays,the main treatments for glaucoma are focused on decreasing IOP;nevertheless,the progression of the disease continues,despite IOP control.This fact shows the existence of other factors that could contribute to the advance of glaucomatous neurodegeneration.The early diagnostics,the use of neuroprotective therapies,and knowledge of the pathological processes are the major challenges associated with the management of this disease.Different pathogenic mechanisms have been proposed to be responsible for RGC death,including oxidative stress,mitochondrial dysfunction,glutamate excitotoxicity,and neuroinflammation(Casson et al.,2012).

关 键 词：IRREVERSIBLE OXIDATIVE activation 

分 类 号：R775[医药卫生—眼科]