谷胱甘肽在肿瘤细胞发生铁死亡过程中的作用研究  

Role of glutathione in ferroptosis of tumor cells

作　　者：杨凤娟 谭宁 张天禹[3] 程潭 Feng-Juan Yang;Ning Tan;Tian-Yu Zhang;Tan Cheng(Department of Human Anatomy,Basic Medical College,Guilin Medical University,Guilin 541199,Guangxi Zhuang Autonomous Region,China;Scientific Experiment Center,Department of Human Anatomy,Basic Medical College Guilin Medical University,Guilin 541199,Guangxi Zhuang Autonomous Region,China;Department of Urology,the Affiliated Hospital,Guilin Medical University,Guilin 541004,Guangxi Zhuang Autonomous Region,China)

机构地区：[1]桂林医学院基础医学院人体解剖学教研室,广西壮族自治区桂林市541199 [2]桂林医学院科学实验中心,桂林医学院基础医学院人体解剖学教研室,广西壮族自治区桂林市541199 [3]桂林医学院附属医院泌尿外科,广西壮族自治区桂林市541004

出　　处：《世界华人消化杂志》2021年第15期901-907,共7页World Chinese Journal of Digestology

基　　金：国家自然科学基金地区基金项目,No.81360326、81360377;广西自然科学基金重点项目,No.2015GXNSFDA139027.

摘　　要：铁死亡是近年发现的一种铁依赖性脂质过氧化和活性氧(reactive oxygen species,ROS)诱导的调节性细胞死亡,其发生过程中伴有ROS水平升高和抗氧化系统的下降--如酶抗氧化剂中谷胱甘肽过氧化物酶和非酶抗氧化剂中谷胱甘肽等.谷胱甘肽是细胞内普遍存在的低分子量抗氧化剂,其稳态水平依赖于所需氨基酸前体吸收速率、酶活性、谷胱甘肽二硫化物的回收以及氧化还原之间的平衡等.目前,靶向谷胱甘肽代谢已被广泛研究用于癌症治疗,与组合疗法相比,作为单一治疗策略的谷胱甘肽耗竭产生了显著的治疗效果.因此,深入认识谷胱甘肽在铁死亡发生过程中的作用,将为癌症治疗提供新的思路和方向.Ferroptosis is a type of iron-dependent lipid peroxidation and reactive oxygen species(ROS)-induced regulatory cell death discovered in recent years,which is accompanied by the increase of ROS level and the decrease of antioxidant system components,such as glutathione peroxidase in enzyme antioxidants and glutathione in non-enzyme antioxidants.Glutathione(GSH)is the predominant low-molecular-weight antioxidant with a ubiquitous distribution inside the cell,and its steady-state level depends on the absorption rate of amino acid precursors,enzyme activity,recovery of glutathione disulfide,and the balance between oxidation and reduction.At present,targeted glutathione metabolism has been used in cancer treatment widely.Compared with combination therapy,GSH depletion as a single treatment strategy has a significant effect.Therefore,further understanding of the role of GSH in ferroptosis will provide new ideas and directions for cancer treatment.

关 键 词：铁死亡 活性氧 谷胱甘肽过氧化物酶 谷胱甘肽 

分 类 号：R730.2[医药卫生—肿瘤]