m6A甲基化在消化系统恶性肿瘤发生与进展中的作用  

Role of m6A methylation in occurrence and progression of digestive system malignancies

作　　者：梁锐煌 朱南星 侯钦 吴灵飞[1] Rui-Huang Liang;Nan-Xing Zhu;Qin Hou;Ling-Fei Wu(Department of Gastroenterology,the 2nd Affiliated Hospital of Shantou University Medical College,Shantou 515041,Guangdong Province,China)

机构地区：[1]汕头大学医学院第二附属医院消化内科,广东省汕头市515041

出　　处：《世界华人消化杂志》2021年第14期747-757,共11页World Chinese Journal of Digestology

基　　金：广东省自然科学基金项目,No.2021A1515012127。

摘　　要：N6-甲基腺嘌呤(N6-methyladenosine,m6A)是高等真核生物信使RNA(messenger RNA,mRNA)上最多的化学修饰之一,与mRNA加工、核输出、翻译以及降解密切相关.m6A修饰主要通过甲基转移酶和去甲基化酶以动态可逆的方式进行调控.m6A在表观遗传水平上通过调控原癌基因、抑癌基因的表达而影响肿瘤生长.越来越多的证据表明,m6A与消化系统恶性肿瘤的发生和进展有关,有望成为肿瘤诊断的分子标志物或药物治疗的潜在靶点.本文就m6A在消化系统恶性肿瘤中的作用进行述评.N6-methyladenosine(m6A)is the most common modification in higher eukaryotic messenger RNA(mRNA),which is closely related to the mRNA processing,nuclear output,translation,and degradation.M6A modification is regulated by methyltransferase and demethylase dynamically and reversibly.M6A plays an essential role in tumors progression by regulating epigenetic modification of tumor suppressor genes and oncogenes.In recent years,more and more studies have shown that m6A is related to the occurrence and development of digestive system malignant tumors and may serve as a novel potential biomarker for the diagnosis and prognosis of digestive cancer.This article reviews the latest progress in the research of m6A in digestive system malignant tumors.

关 键 词：N6-甲基腺嘌呤 信使RNA 甲基化修饰 消化系恶性肿瘤 专家述评 

分 类 号：R735[医药卫生—肿瘤]