HSF1在食管鳞状细胞癌中表达及其与放化疗敏感性的关系  

Relationship of expression of heat shock transcription factor 1 with sensitivity to radiotherapy and chemotherapy in esophageal squamous cell carcinoma

作　　者：黄妹 徐梦婷 韩明[1] 王桂良[1] 陈旋 文剑波[2] Mei Huang;Meng-Ting Xu;Gui-Liang Wang;Ming Han;Xuan Chen(Department of Gastroenterology,Pingxiang People’s Hospital,Affiliated Hospital of Southern Medical University,Pingxiang 337000,Jiangxi Province,China)

机构地区：[1]萍乡市人民医院消化内科,江西省萍乡市337000 [2]萍乡市人民医院消化内科消化内科,江西省萍乡市337000

出　　处：《世界华人消化杂志》2021年第14期775-787,共13页World Chinese Journal of Digestology

摘　　要：背景食管癌发病率及死亡率在全世界都极高,且治疗效果不佳.由于目前对食管癌发病机制尚未完全清楚,这不利于食管癌特异性治疗药物的研究.通过阅读大量文献发现,热休克转录因子1(heat shock transcription fact 1,HSF1)与多种恶性肿瘤的发生发展密切相关,那么HSF1是否也与食管鳞状细胞癌的发生发展密切相关呢?HSF1是否会成为治疗食管鳞状细胞癌的生物靶标呢?在不同中晚期食管鳞状细胞癌患者中,不同患者对放化疗敏感度不一样,已有研究证明,在肝细胞癌中,HSF1会削弱放化疗对肿瘤的毒性作用从而降低疗效,那么HSF1是否会影响食管鳞状细胞癌对放化疗的敏感性呢?目的探究HSF1在食管鳞状细胞癌(esophageal squamous cell carcinoma,ESCC)中表达情况及其表达程度对ESCC放化疗敏感性的影响.方法(1)将92例患者分成4组:ESCCⅠ、Ⅱ期手术切除组20例,ESCCⅢ、Ⅳ期手术切除组18例,ESCCⅢ、Ⅳ期放化疗组44例,其中ESCCⅢ、Ⅳ期放化疗组分为HSF1低表达组16例和高表达组28例食管不典型增生组10例;对照组:食管炎症组10例;(2)取各组病理蜡块通过免疫组化及染色技术检测HSF1在各组表达情况;(3)通过ESCCⅢ、Ⅳ期患者HSF1低表达组及高表达组的非肿瘤病灶大小、肿瘤直径及癌胚抗原(carcinoembryonic antigen,CEA)值在放化疗前后的变化,评估患者对放化疗治疗敏感性;(4)分析影响ESCC手术患者3年生存期的相关因素及ESCC患者3年总体生存率.结果(1)HSF1在各ESCC组中高表达,在食管炎症组及食管不典型增生组中低表达,且各ESCC组与食管炎症组及食管不典型增生组的HSF1表达情况存在差异,P=0.001,有统计学意义;HSF1表达与年龄、性别、肿瘤部位、肿瘤大小、分化程度、T分期、N分期、M分期无关,P>0.05,均无统计学意义;(2)放化疗后,ESCCⅢ、Ⅳ期放化疗组中HSF1低表达组与HSF1高表达组相比,非肿瘤病灶减少更多,肿瘤直径BACKGROUND The morbidity and mortality of esophageal cancer are extremely high all over the world,and the treatment effect is not good.As the pathogenesis of esophageal cancer is not yet fully understood,this is not conducive to the study of specific therapeutic drugs for esophageal cancer.Heat shock transcription fact 1(HSF1)is closely related to the occurrence and development of a variety of malignant tumors.Is HSF1 also closely related to the occurrence and development of esophageal squamous cell carcinoma(ESCC)?Will HSF1 become a biological target for the treatment of ESCC?Different patients with advanced ESCC have different sensitivity to radiotherapy and chemotherapy.Studies have shown that in hepatocellular carcinoma,HSF1 can weaken the toxic effect of radiotherapy and chemotherapy on tumors and reduce the curative effect.Does HSF1 affect the sensitivity of ESCC to radiotherapy and chemotherapy?AIM To investigate the expression of HSF1 in ESCC and its effect on the sensitivity of ESCC to radiotherapy and chemotherapy.METHODS Ninety-two patients were divided into four groups:20 stageⅠ/ⅡESCC patients undergoing surgical resection,18 stageⅢ/ⅡESCC patients undergoing surgical resection,and 44 stageⅢ/ⅡESCC patients undergoing radiotherapy and chemotherapy.Among the 44 stageⅢ/ⅡESCC patients undergoing radiotherapy and chemotherapy,16 had low HSF1 expression and 28 had high expression.Ten cases of esophageal dysplasia.Ten esophagitis tissues were used as a control group.The expression of HSF1 in each group was detected by immunohistochemistry.The changes of non-tumorous lesion size,tumor diameter,and CEA value were compared between the HSF1 low expression group and high expression group before and after radiotherapy and chemotherapy to assess the sensitivity of patients to radiotherapy and chemotherapy.Factors that might affect the 3-year survival of ESCC patients were identified,and the 3-year overall survival rate of ESCC patients was calculated.RESULTS HSF1 was highly expressed in each ESCC gro

关 键 词：热休克转录因子1 食管鳞状细胞癌 放疗 化疗 敏感性 

分 类 号：R735.1[医药卫生—肿瘤]