Usefulness of metagenomic next-generation sequencing in adenovirus 7-induced acute respiratory distress syndrome:A case report  

作　　者：Xiao-Juan Zhang Jia-Yin Zheng Xin Li Ying-Jian Liang Zhi-Dan Zhang 

机构地区：[1]Department of Intensive Care Unit,The First Affiliated Hospital of China Medical University,Shenyang 110001,Liaoning Province,China [2]Department of Infectious Disease,The First Affiliated Hospital of China Medical University,Shenyang 110001,Liaoning Province,China

出　　处：《World Journal of Clinical Cases》2021年第21期6067-6072,共6页世界临床病例杂志

摘　　要：BACKGROUND Direct metagenomic next-generation sequencing(mNGS)of clinical samples is an effective method for the molecular diagnosis of infection.However,its role in the diagnosis of patients with acute respiratory distress syndrome(ARDS)of an unknown infectious etiology remains unclear.CASE SUMMARY A 33-year-old man was admitted to our center for a cough and febrile sensation.Shortly after admission,the patient was diagnosed with ARDS and treated in the intensive care unit.Subsequently,chest computed tomography features suggested an infection.mNGS was performed and the results were indicative of an infection caused by adenovirus type 7.The patient recovered after receiving appropriate treatment.CONCLUSION mNGS is a promising tool for the diagnosis of ARDS caused by infectious agents.However,further studies are required to develop strategies for incorporating mNGS into the current diagnostic process for the disease.

关 键 词：Acute respiratory distress syndrome Metagenomic next-generation sequencing ADENOVIRUS Case report 

分 类 号：R563.8[医药卫生—呼吸系统]