神经纤毛蛋白-1与神经胶质母细胞瘤发生发展的相关性研究进展  

Research Progress on Relationship Between Neurociliary Protein-1 and Occurrence and Development of Glioblastoma

作　　者：倪羽 赵梓彤 李里[1] 姜秋颖[1] NI Yu;ZHAO Zi-tong;LI Li;JIANG Qiu-ying(Second Affiliated Hospital of Harbin Medical University,Harbin 150086,China)

机构地区：[1]哈尔滨医科大学附属第二医院,黑龙江哈尔滨150086

出　　处：《肿瘤学杂志》2021年第7期586-591,共6页Journal of Chinese Oncology

基　　金：国家自然科学基金(81702464)。

摘　　要：神经纤毛蛋白-1(neuropilin-1,NRP1)是一种广泛表达的跨膜蛋白,其在各种肿瘤组织中广泛表达,随肿瘤恶性程度的增加而上调,与肿瘤预后显著相关。胶质母细胞瘤(GBM)是脑恶性肿瘤中最常见、恶性程度最高的肿瘤类型。研究发现,NRP1对于肿瘤的调控和促进作用在神经胶质母细胞瘤(GBM)中更为显著。体内实验表明,NRP1以共受体的形式参与、调节了GBM中血管生长因子的激活,进而促进GBM的发展。全文综述了NPP1的结构与功能特点,以及NRP1参与GBM发生、发展过程的研究进展。Neurociliary protein-1(neuropilin-1, NRP1) is a widely expressed transmembrane protein. In tumor tissues its expression is significantly related to the increased malignancy of tumor and prognosis of patients. Glioblastoma(GBM) is one of the most common and highly malignant brain tumors. Studies have revealed that NRP1, as a co-receptors, is involved in the regulation and activation of vascular growth factors to promote the development of GBM. This article reviews the structural and functional characteristics of NPP1, and the research progress on the relationship between NRP1 and the occurrence and development of GBM.

关 键 词：神经纤毛蛋白-1 神经胶质母细胞瘤 相关性 

分 类 号：R739.41[医药卫生—肿瘤]