In situ Activatable Peptide-based Nanoprobes for Tumor Imaging  

作　　者：LIU Zhiyu LIANG Gaolin ZHAN Wenjun 

机构地区：[1]State Key Laboratory of Bioelectronics,School of Biological Science and Medical Engineering,Southeast University,Nanjing,210096,P.R.China

出　　处：《Chemical Research in Chinese Universities》2021年第4期889-899,共11页高等学校化学研究（英文版）

基　　金：This work was supported by the National Natural Science Foundation of China(Nos.22074016,21725505,81821001).

摘　　要：Owing to its excellent biological properties,peptide has been widely used in the design of nanoprobes capable of enhancing tumor imaging signals.In recent years,a number of peptide-based nanoprobes with strong loading capacity and great biocompatibility have been developed for precision tumor imaging by coupling peptide motifs with different imaging agents.It is worth noting that,compared with“always on”mode,the use of stimulus-mediated in situ activatable mode to design and control the self-assembly or nanostructure transformation of peptide-based nanoprobes in vivo can achieve the significant improvement of imaging efficiency.Herein,we summarize the recent progress of in situ activatable peptide-based nanoprobes for tumor imaging in diverse imaging modes,including magnetic resonance imaging(MRI),fluorescence imaging(FI),photoacoustic imaging(PAI),radionuclide imaging(RI)and multimodal imaging.Finally,we briefly prospect the challenges and potential development directions of this field.

关 键 词：Tumor imaging Peptide-based nanoprobe In situ activatable Self-assembly 

分 类 号：R730[医药卫生—肿瘤] TB383[医药卫生—临床医学]