谷氨酸AMPA受体GluA2/TARPγ-8在癫痫发病中的机制及其干预研究进展  

Progress on the mechanism and intervention of glutamate AMPA receptor GluA2/TARPγ-8 in the pathogenesis of epilepsy

作　　者：王梦露(综述) 王纪文(审校)[1] Wang Menglu;Wang Jiwen(Department of Neurology,Shanghai Children′s Medical Center of Shanghai Jiao Tong University,Shanghai 200127,China)

机构地区：[1]上海交通大学附属上海儿童医学中心神经内科,200127

出　　处：《国际儿科学杂志》2021年第7期455-458,共4页International Journal of Pediatrics

基　　金：国家自然科学基金(8177051141)。

摘　　要：癫痫是一种常见的慢性中枢神经系统疾病,目前认为离子型谷氨酸受体α-氨基-3-羟基-5-甲基-4-异噁唑-丙酸(AMPA)在其发病机制中起着十分重要的作用,AMPA受体(AMPARs)介导与癫痫相关的脑区和脑区间的快速兴奋性突触传递,并在癫痫的发生和癫痫诱发的脑损伤中发挥作用。但由于AMPA受体在中枢神经系统的广泛分布,以及在脑神经发育和通路形成中的重要作用,直接对AMPARs的表达或功能进行调节可能会产生不良后果。海马CA1区作为癫痫现象发生的主要场所,选择性地对在该区高度表达的AMPA受体GluA2亚基和AMPA受体跨膜调节蛋白家族(TARPs)γ-8亚型及其复合体GluA2/TARPγ-8进行调节,是否可以产生抗癫痫作用的同时避免不良反应,该文对此进行综述。Epilepsy occurs as a result of episodic abnormal synchronous discharges in cerebral neuronal networks.It is characterized by an imbalance between excitatory and inhibitory neurotransmission.Although various non-conventional mechanisms are implicated in epileptic synchronization,glutamate excitatory neurons play an essential role.AMPA receptors mediate fast synaptic excitation within and between brain regions relevant to epilepsy,and play a role in epileptogenesis and in seizure-induced brain damage.However,direct modulation of AMPA receptors may have undesirable consequences,given its wide expression within the central nervous system and critical roles on brain circuitry development.Hippocampal CA1 region,as the main site of epilepsy,selectively regulates the high expression of AMPA receptor GluA2 subunit and transmembrane AMPA receptor regulatory protein family(TARPs)γ-8 subtype and its complex GluA2/TARPγ-8,whether it can produce anti-epileptic and avoid adverse reactions.

关 键 词：癫痫 AMPA受体 跨膜AMPA受体跨膜调节蛋白家族 GluA2/TARPγ-8复合物 

分 类 号：R74[医药卫生—神经病学与精神病学]