Fludarabine inhibits type I interferon-induced expression of the SARS-CoV-2 receptor angiotensin-converting enzyme 2  

作　　者：Huiqing Xiu Jiali Gong Tiancha Huang Yanmei Peng Songjie Bai Guirun Xiong Shufang Zhang Huaqiong Huang Zhijian Cai Gensheng Zhang 

机构地区：[1]Department of Critical Care Medicine,Second Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou,China [2]Institute of Immunology,and Department of Orthopaedics of the Second Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou,China [3]Department of Emergency Medicine,Tongde Hospital of Zhejiang Province,Hangzhou,China [4]Department of Cardiology,Second Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou,China [5]Key Laboratory of Respiratory Disease of Zhejiang Province,Department of Respiratory and Critical Care Medicine,Second Affiliated Hospital of Zhejiang University School of Medicine,Hangzhou,Zhejiang,China

出　　处：《Cellular & Molecular Immunology》2021年第7期1829-1831,共3页中国免疫学杂志（英文版）

基　　金：supported by grants from the Natural Science Foundation of Zhejiang Province(No.LY19H150007,G.SZ);National Natural Science Foundations of China(No.81971871,G.SZ;No.81901941,S.F.Z.);National Key R&D Program of China(2017YFC1310604,H.Q.H.).

摘　　要：Angiotensin-converting enzyme 2(ACE2)is the receptor for severe acute respiratory syndrome coronavirus(SARS-CoV)and SARS-CoV-2 and is upregulated after infection with these viruses,which assists the entry of these viruses into the target cells.1,2,3 In addition,ACE2 is a human interferon-stimulated gene.4 In response to viral infection,host cells produce vast amounts of type I interferon(IFN)to defend against viral infection.5 Type I IFNs,such as IFN-α,can upregulate the phosphorylation of signal transducer and activator of transcription 1(STAT1)and 2(STAT2).6,7 Thus,whether and how IFN-αcould promote and whether blockade of the IFN-α-STAT pathway could inhibit the expression of ACE2 are largely unknown.Given the importance of ACE2 for SARS-CoV-2 invasion and the clinical practice of IFN treatment to combat viral infection,herein,we addressed these issues via a series of in vitro experiments.

关 键 词：ACE2 INTERFERON INVASION 

分 类 号：R392[医药卫生—免疫学]