脑库神经系统变性疾病的病理诊断  

Neurodegenerative diseases pathological diagnosis in brain bank

作　　者：竺可青[1] 毛晨晖[2] 杜鹃[3] 张蕾[1] Zhu Keqing;Mao Chenhui;Du Juan;Zhang Lei(National Human Brain Bank for Health and Disease,Zhejiang University School of Medicine;Department of Neurology,Peking Union Medical College Hospital;Teaching and Research Section of Anatomy,Hebei Medical University,Human Brain Bank of Hebei Medical University)

机构地区：[1]浙江大学医学院国家健康与疾病人脑组织资源库,杭州310058 [2]北京协和医院神经内科,北京100730 [3]河北医科大学人体解剖学教研室、河北医科大学人脑组织库,石家庄050017

出　　处：《重庆医科大学学报》2021年第7期781-785,共5页Journal of Chongqing Medical University

基　　金：国家自然科学基金面上资助项目(编号:81971184)。

摘　　要：随着脑计划在国内的开展,脑库工作将在其中起重要作用。神经系统变性疾病为脑库相关疾病的重要组成部分,对其进行严格的神经病理诊断具有重要意义。本文结合作者在脑库工作中的经验,对常见神经系统变性疾病的病理特点进行重点概述,对近年来在阿尔茨海默病、原发性衰老相关性tau病等疾病的病理诊断进展进行介绍,力图建立脑库神经系统变性疾病病理诊断的标准化程序。With the development of brain project in China,brain bank work will play an important role in the project. Neurodegenerative diseases contribute an important part in brain bank diseases,and it is of great significance to make a strict neuropathological diagnosis. In this article,combined with the author ’s working experience in brain bank,this paper focuses on summarizing the pathological characteristics of common neurodegenerative diseases,and introduces the pathological diagnosis progress of Alzheimer’s disease,primary aging-related tauopathy and other diseases introduced in recent years,trying to establish a standardized procedure for pathological diagnosis of neurodegenerative diseases in brain bank.

关 键 词：脑库 神经系统变性疾病 阿尔茨海默病 原发性衰老相关性tau病 

分 类 号：R741.04[医药卫生—神经病学与精神病学]