小剂量长期慢性照射介入放射学工作人员细胞遗传学指标分析  

Analysis of cytogenetic indexes in interventional radiology workers exposed to low dose long-term chronic irradiation

作　　者：陆雪[1] 封江彬[1] 田雪蕾[1] 李爽[1] 吕玉民 刘青杰[1] LU Xue;FENG Jiang-bin;TIAN Xue-lei;LI Shuang;LÜ Yu-min;LIU Qing-jie(National Institute for Radiological Protection,Chinese Center for Disease Control and Prevention/China CDC Key Laboratory of Radiological Protection and Nuclear Emergency,Beijing 100088,China;不详)

机构地区：[1]中国疾病预防控制中心辐射防护与核安全医学所,辐射防护与核应急中国疾病预防控制中心重点实验室,北京100088 [2]河南省职业病防治研究院,河南郑州450052

出　　处：《中国职业医学》2021年第2期208-212,共5页China Occupational Medicine

基　　金：国家自然科学基金(81573081)。

摘　　要：目的观察小剂量长期慢性照射对介入放射学工作人员周围血淋巴细胞染色体畸变和微核的影响。方法采用方便抽样方法,以100名河南省三级甲等医院的介入放射学工作人员为介入组,以78名无接触射线的健康人群为对照组,检测2组人群周围血淋巴细胞染色体畸变和微核率。结果介入组人群无着丝粒体(ace)细胞率、双着丝粒体(dic)细胞率、相互易位(t)细胞率、染色体型畸变细胞率和总畸变细胞率均高于对照组(0.55%vs 0.30%,0.25%vs 0.03%,0.38%vs 0.01%,1.21%vs 0.34%,1.37%vs 0.54%,P值均<0.01)。介入组人群中,染色体型畸变细胞率高于染色单体断裂细胞率(1.21%vs 0.16%,P<0.01),非稳定性染色体畸变细胞率高于稳定性染色体畸变细胞率(0.80%vs 0.41%,P<0.01);各型染色体型畸变细胞率由高到低排列依次为ace细胞率、t细胞率、dic细胞率和缺失细胞率(P<0.01)。介入组人群微核细胞率和微核率均高于对照组(0.86‰vs 0.40‰,0.89‰vs 0.41‰,P值均<0.01)。介入组女性亚组人群微核细胞率和微核率均高于男性亚组(1.12‰vs 0.62‰,1.19‰vs 0.62‰,P值均<0.01)。结论小剂量长期慢性照射对介入放射学工作人员染色体畸变和微核均可造成影响;其染色体畸变主要以非稳定性染色体畸变ace、dic和稳定性染色体畸变t为主。Objective To observe the effect of low dose long-term chronic irradiation on chromosome aberration and micronucleus in peripheral blood lymphocytes of interventional radiology workers.Methods A total of 100 interventional radiology workers in a grade A tertiary hospital of Henan Province were selected as the interventional group using a convenient sampling method,and 78 healthy individuals without radiation exposure were selected as the control group.The incidence of chromosomal aberration and micronucleus of peripheral blood lymphocytes in individuals of these two groups were investigated.Results The frequencies of cells with acentric fragment(ace),dicentric chromosome(dic),reciprocal translocation(t),chromosome type aberration and total aberration in the interventional group were higher than those in the control group,and the differences were statistically significant(0.55%vs 0.30%,0.25%vs 0.03%,0.38%vs 0.01%,1.21%vs 0.34%,1.37%vs 0.54%,all P<0.01).In the interventional group,the frequency of cell with chromosome type aberration was higher than that of chromatid type aberration(1.21%vs 0.16%,P<0.01).The frequency of cell with unstable chromosome aberration was higher than that of stable chromosome aberration(0.80%vs 0.41%,P<0.01),and the frequency of cell with chromosomal type aberrant in the interventional group ranked from high to low in order of ace,t,dic and deletion(P<0.01).The incidence of micronuclear cells and micronucleus in the interventional group were higher than those in the control group(0.86‰vs 0.40‰,0.89‰vs 0.41‰,all P<0.01).The incidence of micronuclear cells and micronucleus of female interventional radiology workers were higher than those of male workers(1.12‰vs 0.62‰,1.19‰vs 0.62‰,all P<0.01).Conclusion Low dose and long-term chronic irradiation exposure can affect both chromosome aberration and micronucleus of interventional radiology workers.The main chromosomal aberrations were non-stable chromosomal aberrations ace,dic and stable chromosomal aberrations t.

关 键 词：介入放射学 放射工作人员 淋巴细胞 染色体畸变 微核 

分 类 号：R149[医药卫生—军事预防医学]