环糊精及其衍生物在药物制剂中的应用  

Application of Cyclodextrin and Its Derivatives in Pharmaceutical Preparations

作　　者：肖姗姗 吉时蕾 蒋欣欣 韩军 XIAO Shanshan;JI Shilei;JIANG Xinxin;HAN Jun(Biopharmaceutical Research Institute,Liaocheng University,Liaocheng 252059,China;Liaocheng High-tech Biotechnology Co.,Ltd,Liaocheng 252059,China)

机构地区：[1]聊城大学生物制药研究院,山东聊城252059 [2]聊城高新生物技术有限公司,山东聊城252059

出　　处：《聊城大学学报（自然科学版）》2021年第6期77-83,91,共8页Journal of Liaocheng University:Natural Science Edition

基　　金：“重大新药创制”科技重大专项2017年度立项课题(2017ZX09201003);山东省抗体药物协同创新中心开放课题项目(CIC-AD1828、1838、1839)资助。

摘　　要：环糊精是由α-1,4糖苷键连接的且具有锥形中空圆筒立体环状结构的一系列环状低聚糖的总称。其具有热稳定性良好、结构易于修饰等优势,在食品、医药等领域表现出极大的应用前景。强大的载药能力以及其结构的易于修饰等性质,使环糊精成为药物制剂领域的研究热点之一。总结了环糊精及其衍生物的分子结构、研究现状及其在药物制剂领域的应用。最后,对环糊精在药剂领域的发展前景进行了展望。Cyclodextrins are the general term for a series of cyclic oligosaccharides connected byα-1,4 glycosidic bonds with a conical,hollow and cylindrical three-dimensional-ring structure.It has the advantages of good thermal stability and easy modification of the structure,and has shown great application prospects in the fields of food and medicine.Cyclodextrins have become one of the research hotspots in the field of pharmaceutical preparations because of its strong drug loading capacity and easy modification of its structure.In this paper,the molecular structure,research status and application of cyclodextrins and their derivatives in pharmaceutical preparation are summarized and reviewed.Finally,some views about the development prospect of cyclodextrins in pharmaceutical field was pointed out.

关 键 词：环糊精 药物制剂 包合作用 药物递送 

分 类 号：R944.9[医药卫生—药剂学]