Coexistent vestibular schwannoma and meningioma in a patient without neurofibromatosis:A case report and review of literature  

作　　者：Li-Yan Zhao Yi-Ning Jiang Yu-Bo Wang Yang Bai Ying Sun Yun-Qian Li 

机构地区：[1]Department of Clinical Laboratory,Second Hospital of Jilin University,Changchun 130041,Jilin Province,China [2]Department of Neurosurgery,First Hospital of Jilin University,Changchun 130021,Jilin Province,China

出　　处：《World Journal of Clinical Cases》2021年第24期7251-7260,共10页世界临床病例杂志

摘　　要：BACKGROUND The simultaneous occurrence of schwannoma and meningioma in the absence of neurofibromatosis(NF)or a previous history of irradiation is exceedingly rare,as only 10 intracranial cases have been reported to date.Herein,we report a case of a coexistent cavernous sinus meningioma and ipsilateral vestibular schwannoma(VS)in a female patient without NF or a history of exposure to irradiation.CASE SUMMARY A 63-year-old woman presented with progressive left-side hearing loss and tinnitus over the previous year.In the past 6 mo,she developed facial numbness and intermittent headaches.Magnetic resonance imaging showed two lesions that were located on the left side of the cerebellopontine angle and parasellar region.Both lesions were totally resected via the left retrosigmoid approach.Histopathological examination revealed a VS and a meningioma.The patient did not have a family history or clinical or radiological signs of NF.CONCLUSION The coincident occurrence of VS and meningioma within close vicinity is very rare,and the pathogenesis is unclear.A careful whole-body examination needs to be conducted to exclude NF.Surgical treatment with the goal of total tumor resection is the best therapy.Additional studies are needed for a better understanding of the mechanisms that lead to the development of tumor growth in multiple locations.

关 键 词：CONCURRENT Diagnosis MENINGIOMA NEUROFIBROMATOSIS SCHWANNOMA Case report 

分 类 号：R739.4[医药卫生—肿瘤]