NF1相关神经纤维瘤炎症微环境的研究进展  

Research progress of inflammatory microenvironment in NF1 related neurofibroma

作　　者：游元和 王延安[1] YOU Yuan-he;WANG Yan-an(Department of Oromaxillofacial Head and Neck Oncology,Shanghai Ninth Peopled Hospital,Shanghai Jiao Tong University School of Medicine,College of Stomatology,Shanghai Jiao Tong University,National Center for Stomatology,National Clinical Research Center for Oral Diseases,Shanghai Key Laboratory of Stomatology,Shanghai 200011,China)

机构地区：[1]上海交通大学医学院附属第九人民医院口腔颌面-头颈肿瘤科,上海交通大学口腔医学院,国家口腔医学中心,国家口腔疾病临床医学研究中心,上海市口腔医学重点实验室,上海200011

出　　处：《中国口腔颌面外科杂志》2021年第4期376-379,共4页China Journal of Oral and Maxillofacial Surgery

摘　　要：神经纤维瘤是I型神经纤维瘤病的特征性症状之一,终生进展,治疗难度大,而其发病机制仍不明确。瘤内的施万细胞呈NF1双等位基因失活状态,可激活RAS-GTP信号转导,继而释放大量细胞因子,为免疫细胞的募集提供了富含细胞因子的微环境。相较于免疫炎症细胞在正常外周神经中的低占比率,在NF1相关神经纤维瘤中,30%的细胞是单核细胞/巨噬细胞,亦可见肥大细胞、T细胞和树突状细胞。越来越多的研究表明,炎症与肿瘤的形成密切相关。本文从肿瘤炎症微环境方面综述NF1相关神经纤维瘤微环境内相关炎症细胞的研究进展。Neurofibroma is one of the characteristic lesions of neurofibromatosis type 1. However, the pathogenesis of neurofibromas is still not completely known. The highly active RAS-GTP signal transduction of Schwann cells with biallel-ic inactivation can produce a large number of cytokines, which provides a cytokine-rich microenvironment for immune cell recruitment. In normal peripheral nerves, the proportion of immune inflammatory cells is not high. In NF1-related neurofibromas, 30% of the cells are monocytes/macrophages. Mast cells, T cells and dendritic cells(DC) also present. Increased evidences indicate that there is a correlation between inflammation and tumorigenesis. This review summarized the research progress of inflammatory cells in the microenvironment of NF1-related neurofibroma.

关 键 词：Ⅰ型神经纤维瘤病 神经纤维瘤 肥大细胞 巨噬细胞 肿瘤炎症微环境 

分 类 号：R739.8[医药卫生—肿瘤]