重复经颅磁刺激联合西酞普兰治疗老年抑郁症的临床疗效分析  

Analysis of clinical efficacy of repetitive transcranial magnetic stimulation combined with citalopram in the treatment of senile depression

作　　者：王春雨 夏小华 WANG Chun-yu;XIA Xiao-hua(Dongtai Third People’s Hospital,Dongtai 224200,China)

机构地区：[1]江苏省东台市第三人民医院,224200

出　　处：《中国实用医药》2021年第24期80-82,共3页China Practical Medicine

摘　　要：目的研究分析重复经颅磁刺激(rTMS)联合西酞普兰对老年抑郁症的治疗效果。方法60例老年抑郁症患者,按照随机抽样的方法分为对照组与观察组,各30例。对照组患者采用西酞普兰进行治疗,观察组患者在对照组基础上联合重复经颅磁刺激进行治疗。对比两组患者疗效,治疗前后汉密尔顿抑郁量表(HAMD)、自杀意念自评量表(SIOSS)评分,不良反应发生情况。结果两组患者治疗期间无脱落病例。治疗后,观察组患者的治疗总有效率83.3%高于对照组的33.3%,差异具有统计意义(P<0.05)。对照组患者治疗前的HAMD、SIOSS评分分别为(23.61±5.35)、(17.42±3.47)分,治疗后分别为(16.23±4.09)、(12.36±3.21)分;观察组患者治疗前的HAMD、SIOSS评分分别为(25.16±4.75)、(18.75±3.67)分,治疗后分别为(12.37±3.89)、(10.08±2.67)分。治疗前,两组患者的HAMD、SIOSS评分对比差异无统计学意义(P>0.05);治疗后,两组患者的HAMD、SIOSS评分均低于治疗前,且观察组患者的HAMD、SIOSS评分均低于对照组,差异具有统计学意义(P<0.05)。在治疗过程中,对照组患者不良反应发生率为6.67%,观察组患者不良反应发生率为10.00%;两组患者的不良反应发生率对比差异无统计学意义(P>0.05)。结论利用重复经颅磁刺激联合西酞普兰对老年抑郁症患者进行治疗,可有效抑制患者的自杀意念,具有更强的治疗效果。Objective To study and analyze the therapeutic effect of repetitive transcranial magnetic stimulation(rTMS)combined with citalopram in the treatment of senile depression.Methods A total of 60 senile patients with depression were divided into control group and observation group according to random lottery method,with 30 cases in each group.The control group was treated with citalopram,and the observation group was treated with repetitive transcranial magnetic stimulation based on the control group.The clinical efficacy,Hamilton depression scale(HAMD)and self-rating idea of suicide scale(SIOSS)score,and occurrence of adverse rections were compared between the two groups.Results There were no drop-out cases in the two groups during the treatment.After treatment,the total effective rate 83.3%of the observation group was higher than 33.3%of the control group,and the difference was statistically significant(P<0.05).In the control group,the HAMD and SIOSS score before treatment were(23.61±5.35)and(17.42±3.47)points,which were(16.23±4.09)and(12.36±3.21)points after treatment;in the observation group,the HAMD and SIOSS score before treatment were(25.16±4.75)and(18.75±3.67)points,which were(12.37±3.89)and(10.08±2.67)points after treatment.Before treatment,there was no statistically significant difference in HAMD and SIOSS score between the two groups(P>0.05).After treatment,the HAMD and SIOSS score of the two groups were lower than those before treatment,and the observation group was lower than the control group.All the difference was statistically significant(P<0.05).During treatment,the incidence of adverse reactions of the observation group was 6.67%,which was 10.00%of the observation group,and the difference was not statistically significant(P>0.05).Conclusion Combination of repetitive transcranial magnetic stimulation and citalopram can effectively inhibit suicidal ideation in senile patients with depression,and has a stronger therapeutic effect.

关 键 词：西酞普兰 重复经颅磁刺激 老年抑郁症 

分 类 号：R749.4[医药卫生—神经病学与精神病学]