B7 homologue 3 as a prognostic biomarker and potential therapeutic target in gastrointestinal tumors  

作　　者：Petar Rasic Maja Jovanovic-Tucovic Marija Jeremic Slavisa M Djuricic Zorica V Vasiljevic Maja Milickovic Djordje Savic 

机构地区：[1]Department of Abdominal Surgery,Mother and Child Health Care Institute of Serbia“Dr.Vukan Cupic”,Belgrade 11000,Serbia [2]Institute of Medical and Clinical Biochemistry,School of Medicine,University of Belgrade,Belgrade 11000,Serbia [3]Department of Clinical Pathology,Mother and Child Health Care Institute of Serbia“Dr.Vukan Cupic”,Belgrade 11000,Serbia [4]Faculty of Medicine,University of Banja Luka,Banja Luka 78000,Bosnia and Herzegovina [5]Department of Clinical Microbiology,Mother and Child Health Care Institute of Serbia“Dr.Vukan Cupic”,Belgrade 11000,Serbia [6]School of Medicine,University of Belgrade,Belgrade 11000,Serbia

出　　处：《World Journal of Gastrointestinal Oncology》2021年第8期799-821,共23页世界胃肠肿瘤学杂志（英文版）（电子版）

摘　　要：The most common digestive system(DS)cancers,including tumors of the gastrointestinal tract(GIT)such as colorectal cancer(CRC),gastric cancer(GC)and esophageal cancer(EC)as well as tumors of DS accessory organs such as pancreatic and liver cancer,are responsible for more than one-third of all cancerrelated deaths worldwide,despite the progress that has been achieved in anticancer therapy.Due to these limitations in treatment strategies,oncological research has taken outstanding steps towards a better understanding of cancer cell biological complexity and heterogeneity.These studies led to new molecular target-driven therapeutic approaches.Different in vivo and in vitro studies have revealed significant expression of B7 homologue 3(B7-H3)among the most common cancers of the GIT,including CRC,GC,and EC,whereas B7-H3 expression in normal healthy tissue of these organs was shown to be absent or minimal.This molecule is able to influence the biological behavior of GIT tumors through the various immunological and nonimmunological molecular mechanisms,and some of them are shown to be the result of B7-H3-related induction of signal transduction pathways,such as Janus kinase 2/signal transducer and activator of transcription 3,phosphatidylinositol 3-kinase/protein kinase B,extracellular signal-regulated kinase,and nuclear factor-κB.B7-H3 exerts an important role in progression,metastasis and resistance to anticancer therapy in these tumors.In addition,the results of many studies suggest that B7-H3 stimulates immune evasion in GIT tumors by suppressing antitumor immune response.Accordingly,it was observed that experimental depletion or inhibition of B7-H3 in gastrointestinal cancers improved antitumor immune response,impaired tumor progression,invasion,angiogenesis,and metastasis and decreased resistance to anticancer therapy.Finally,the high expression of B7-H3 in most common cancers of the GIT was shown to be associated with poor prognosis.In this review,we summarize the established data from different GIT cancer-related

关 键 词：B7 homologue 3 Gastrointestinal tumors Colorectal cancer Gastric cancer Esophageal cancer Targeted therapy 

分 类 号：R735[医药卫生—肿瘤]