缺血性脑卒中患者阿司匹林抵抗的发生机制与防治策略  

Mechanisms and Prevention and Control Strategy of Aspirin Resistance in Patients with Ischemic Stroke

作　　者：刘莎 康蓓[2] 郭荷娜[2] 杨芾 杨谦[2] LIU Sha;KANG Bei;GUO Hena;YANG Fu;YANG Qian(Xi′an Medical University,Xi′an 710068,China;Department Two of Neurology,Shaanxi Provincial People′s Hospital,Xi′an 710068,China;Department of Pediatrics,the First Affiliated Hospital of Xi′an Medical University,Xi′an 710077,China)

机构地区：[1]西安医学院,西安710068 [2]陕西省人民医院神经内二科,西安710068 [3]西安医学院第一附属医院儿科,西安710077

出　　处：《医学综述》2021年第15期2962-2966,共5页Medical Recapitulate

摘　　要：缺血性脑卒中是最常见的脑血管疾病,是造成我国成年人残疾及死亡的首要原因。阿司匹林具有抗血小板作用,是治疗缺血性脑卒中的常用药,而阿司匹林抵抗是导致缺血性脑卒中患者二级预防及预后欠佳的重要原因。导致阿司匹林抵抗的原因与阿司匹林本身、血小板以及相关酶类有关,未来针对此方面进行深入探索并结合实验室检查,对服用阿司匹林的患者进行早期评估并采取针对性的干预措施,可提高阿司匹林抗血小板治疗的疗效,改善缺血性脑卒中患者预后。Ischemic stroke is the most common cerebrovascular disease and the leading cause of disability and death in Chinese adults.Aspirin has antiplatelet effect and is a common drug in the treatment of ischemic stroke,however,aspirin resistance is an important reason for the poor secondary prevention and prognosis in the patients with ischemic stroke.The cause of aspirin resistance is related to aspirin itself,platelets and related enzymes.In the future,deep exploration of these aspects in combination with laboratory examination,early evaluation and targeted intervention measures for patients taking aspirin can improve the efficacy of antiplatelet therapy with aspirin,and improve the prognosis of ischemic stroke.

关 键 词：缺血性脑卒中 阿司匹林抵抗 发生机制 防治策略 

分 类 号：R743.32[医药卫生—神经病学与精神病学] R743.33[医药卫生—临床医学]