噻托溴铵联合血必净注射液辅以腹式-缩唇呼吸锻炼治疗慢性阻塞性肺疾病急性加重期的临床效果  

Clinical Efficacy of Tiotropium Bromide Combined with Xuebijing Injection and Half-closed Lip Abdominal Respiration Training in Treatment of Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease

作　　者：路彩霞 张玲慧[2] 张志军[2] 包宪霞[2] 高继霞[2] 孙洁 高晓粉 LU Cai-xia;ZHANG Ling-hui;ZHANG Zhi-jun;BAO Xian-xia;GAO Ji-xia;SUN Jie;GAO Xiao-fen(Emergency Department,Cangzhou Hospital of Integrated Traditional Chinese Medicine and Western Medicine,Cangzhou,Hebei 061000,China;Department of Internal Medicine,Shijiazhuang Medical College,Shijiazhuang 050071,China)

机构地区：[1]河北省沧州中西医结合医院急诊科,河北沧州061000 [2]石家庄医学高等专科学校内科教研室,石家庄050071

出　　处：《临床误诊误治》2021年第8期27-31,共5页Clinical Misdiagnosis & Mistherapy

基　　金：河北省科技厅研究课题计划项目(20160842);河北省医学科学研究重点课题计划项目(20211803);石家庄市科学技术研究与发展指导计划项目(161462763)。

摘　　要：目的观察噻托溴铵联合血必净注射液辅以腹式-缩唇呼吸锻炼治疗慢性阻塞性肺疾病急性加重期(AECOPD)的临床效果。方法选取2016年6月—2020年12月收治的AECOPD 190例,根据治疗方法的不同分为对照组和观察组,每组95例,对照组给予噻托溴铵治疗,观察组在对照组基础上给予血必净注射液辅以腹式-缩唇呼吸锻炼。治疗2周后,比较两组的临床疗效,以及治疗前后肺功能指标、慢性阻塞性肺疾病评估测试(CAT)评分、血清降钙素原(PCT)、C反应蛋白(CRP)、白细胞介素-6(IL-6)水平,并观察治疗过程中的不良反应。结果观察组治疗总有效率高于对照组(P<0.01)。治疗后,两组第1秒用力呼气容积(FEV1)、用力肺活量(FVC)、FEV1/FVC均较治疗前升高,且观察组高于对照组(P<0.05,P<0.01)。治疗后,两组CRP、PCT、IL-6水平和CAT评分均较治疗前降低,且观察组低于对照组(P<0.05,P<0.01)。两组在治疗过程中均无严重不良反应发生。结论噻托溴铵联合血必净注射液辅以腹式-缩唇呼吸锻炼对AECOPD的临床疗效肯定,能明显改善肺功能,减轻炎症反应,且不增加不良反应发生率。Objective To investigate clinical efficacy of Tiotropium Bromide combined with Xuebijing Injection and half-closed lip abdominal respiration training in treatment of patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods A total of 190 AECOPD patients admitted between June 2016 and December 2020 were selected and divided into control group(n=95)and observation group(n=95)according to different therapeutic methods.Control group was treated with Tiotropium Bromide,while observation group was added with Xuebijing Injection and half-closed lip abdominal respiration training on the basis of treatment for control group.After treatment for 2 weeks,clinical efficacy,lung function indexes,chronic obstructive pulmonary disease assessment test(CAT)scores,serum procalcitonin(PCT),C-reactive protein(CRP)and interleukin-6(IL-6)levels before and after treatment were compared,and adverse reactions during the treatment were observed in two groups.Results The total effective rate in observation group was significantly higher than that in control group(P<0.01).After treatment,values of forced expiratory volume in one second(FEV1),forced vital capacity(FVC)and ratio of FEV1/FVC were significantly higher than those before treatment in two groups,and the values in observation group were significantly higher than those in control group(P<0.05,P<0.01).After treatment,levels of CRP,PCT,IL-6 and CAT scores were significantly lower than those before treatment in two groups,and the levels in observation group were significantly lower than those in control group(P<0.05,P<0.01).There were no serious adverse reactions during the treatment in two groups.Conclusion Tiotropium Bromide combined with Xuebijing Injection and half-closed lip abdominal respiration training in treatment of patients with AECOPD has definite clinical efficacy,which may significantly improve lung function and reduce inflammatory reaction without increasing incidence rate of adverse reactions.

关 键 词：肺疾病 慢性阻塞性 噻托溴铵 血必净注射液 腹式-缩唇呼吸锻炼 用力肺活量 

分 类 号：R563.9[医药卫生—呼吸系统]