早期腹腔灌洗联合静脉滴注乌司他丁治疗高脂血症性重症急性胰腺炎的疗效分析  

Curative Effect of Treating Hyperlipidemia Severe Acute Pancreatitis with Early Peritoneal Lavage Combined with Ulinastatin

作　　者：吴林[1] 郑晓彬 郑桂贞[1] 庄怡哲 Wu Lin;Zheng Xiaobin;Zheng Guizhen(Department of Digestive System,Central Hospital of Shantou,Shantou,Guangdong 515031,China)

机构地区：[1]汕头市中心医院,广东汕头515031

出　　处：《四川医学》2021年第7期685-689,共5页Sichuan Medical Journal

基　　金：汕头市医疗卫生科技计划项目(编号:汕府科[2020]5号-23)。

摘　　要：目的研究早期腹腔灌洗联合乌司他丁静滴治疗高脂血症性重症急性胰腺炎的效果。方法选取2019年7月至2020年7月于我院就诊治疗的高脂血症性重症急性胰腺炎患者100例,随机分为两组(对照组及治疗组),两组均予常规治疗,同时治疗组予早期腹腔灌洗联合乌司他丁静滴治疗,通过血脂、炎症及肠道屏障功能等关键指标水平和首次排气时间、胃肠引流量、住院时间等康复指标对比分析治疗结果。结果治疗后比较,治疗组在TC、TG、WBC、CRP的改善程度均明显优于对照组(P<0.05);治疗组对关于机体康复的肠道屏障功能的相关乳酸、血淀粉酶水平也有明显改善(P<0.05);治疗组中首次排气时间、胃肠引流量、住院时间优于对照组(P<0.05)。结论在高脂血症性重症急性胰腺炎的内科治疗中,予以早期腹腔灌洗联合乌司他丁静滴疗法具有一定疗效,值得推广。Objective To study effects of early peritoneal lavage combined with ulinastatin in the treatment of hyperlipidemia severe acute pancreatitis(HSAP).Methods From July 2019 to July 2020,100 patients with HSAP in our hospital were randomly divided into control group(CG)and treatment group(TG).Both groups were given conventional symptomatic treatment,while TG was given early peritoneal lavage combined with ulinastatin intravenous drip.Treatment results were compared and analyzed,including blood lipids,inflammation,intestinal barrier function,the first exhaust time,gastrointestinal drainage and hospital stay.Results After treatment,TC,TG,WBC and CRP in TG was significantly better than that in CG(P<0.05).In TG,lactic acid and blood amylase were also significantly improved(P<0.05).The first exhaust time,gastrointestinal drainage volume and hospitalization time were better than those in CG(P<0.05).Conclusion Early peritoneal lavage combined with ulinastatin intravenous drip therapy would have a certain effect for HSAP that is worthy of promotion.

关 键 词：高脂血症性重症急性胰腺炎 早期腹腔灌洗 乌司他丁 血脂 炎症因子 

分 类 号：R576[医药卫生—消化系统]