聚肌胞皮损内注射联合加大剂量薏苡仁水煎液内服治疗扁平疣的临床疗效观察  

Observation on Clincical Efficacy of Polyinosity Intralesional Injection Combined with Increased Dose of Coix Seed Decoction Orally Taken to Treat Flat Warts

作　　者：刘林峰[1] Liu Linfeng(Dujiangyan City People′s Hospital,Chengdu,Sichuan 611830,China)

机构地区：[1]都江堰市人民医院,四川成都611830

出　　处：《四川医学》2021年第7期689-692,共4页Sichuan Medical Journal

摘　　要：目的探索聚肌胞皮损内注射联合加大剂量薏苡仁水煎液内服治疗扁平疣的临床疗效。方法将符合扁平疣患者135例随机分成三组,试验组A组、对照组B组和对照组C组各45例。试验组A组(n=45)给予皮损内注射聚肌胞注射液,每周1次;同时每日给予加大剂量薏苡仁90 g水煎600 ml分3次内服。对照组B组(n=45)给予皮损内注射聚肌胞注射液,每周1次。对照组C组(n=45)给予皮损内注射聚肌胞注射液,每周1次;同时每日给予常规剂量薏苡仁30 g水煎600 ml分3次内服。三组治疗疗程均为8周。治疗结束后,对三组的临床疗效进行比较。治疗结束3个月后,对三组基本治愈患者进行随访,记录三组的复发病例数,比较三组的复发率。结果试验组A组的临床疗效率明显高于对照组B组和对照组C组,差异有统计学意义(P<0.05);而对照组B组和C组临床疗效比较,差异无统计学意义(P>0.05)。试验组A组和对照组C组两组的复发率比较,差异无统计学意义(P>0.05);而试验组A组和对照组C组的复发率均明显低于对照组B组,差异有统计学意义(P<0.05)。结论聚肌胞皮损内注射联合常规剂量薏苡仁水煎液内服比聚肌胞皮损内注射治疗扁平疣复发率更低,但临床疗效无明显差异。而聚肌胞皮损内注射联合加大剂量薏苡仁水煎液内服比聚肌胞皮损内注射治疗扁平疣复发率更低,且临床疗效更加明显。Objective To explore the clinical effect of polyinosinic-polycytidylic acid injection co-operate with large dose of coix seed in the treatment of flat warts.Methods 135 patients of flat warts were randomly divided into group A(n=45),group B(n=45)and group C(n=45).Based on comprehensive treatment,group A were given polyinosity intralesional injection at once a week.And 90 g/600 ml increased dose of coix seed decoction orally was added at three times for one day with 200 ml once.While group B were given polyinosity intralesional injection at once a week.Group C were given polyinosity intralesional injection at once a week.And 30 g/600 ml routine dose of coix seed decoction orally was added at three times for one day with 200 ml once.All groups were treated for 8 weeks.Clinical effects were compared after treatment.3 months after finishing treatment,all patients were recorded and compared recurrence rate.Results After treatment,the clinical effect in group A was better than group B and group C(P<0.05),but the clinical effect in group B and group C was close(P>0.05).The recurrence rate in the group A and group C was close(P>0.05),while the recurrence rate in the group A and group C was lower than the recurrence rate in the group B(P<0.05).Conclusion Polyinosity intralesional injection combined with routine dose of coix seed decoction would be more effectivdy and less clinical effect than polyinosity intralesinal injection.However,polyinosity intralesional injection combined with increased dose of coix seed decorction would be more effetively and clinial effect.

关 键 词：扁平疣 聚肌胞 皮损内注射 薏苡仁 水煎液 

分 类 号：R752.22[医药卫生—皮肤病学与性病学]