Rosa机器人辅助立体定向颅内活检术的临床应用  

Clinical application of Rosa robot-assisted stereotactic intracranial biopsy

作　　者：邬立 孙允伟 陆斌 周子健 李方宝 李洛[1] WU Li;SUN Yun-wei;LU Bin;ZHOU Zi-jian;LI Fang-bao;LI Luo(Department of Neurosurgery,Eastern Branch,Qingdao Municipal Hospital,Qingdao 266000,China)

机构地区：[1]青岛大学附属青岛市市立医院东院神经外科,山东青岛266000

出　　处：《中国临床神经外科杂志》2021年第8期584-586,共3页Chinese Journal of Clinical Neurosurgery

摘　　要：目的探讨Rosa机器人辅助下立体定向颅内活检术的临床应用效果。方法回顾性分析2018年10月至2020年8月在Rosa机器人辅助下进行颅内占位立体定向活检术的33例病人的临床资料。结果术中没有发生导航故障,所有程序都如期完成。33例进行76个靶点穿刺活检术,术后未发现颅内出血,术后无癫痫发作。33例活检阳性率为100%,其中胶质瘤21例,弥漫大B细胞淋巴瘤5例,血管畸形2例,转移性腺瘤1例,生殖细胞肿瘤2例,间变性脑膜瘤1例,炎性脱髓鞘1例。21例胶质瘤中,检测出IDH-1突变6例(28.6%),MGMT启动子甲基化16例(76.2%)。1例间变性少突胶质细胞瘤检测出1p/19q杂合性缺失。结论Rosa机器人辅助立体定向无框架活检术是一种相对安全,可行的操作,可用于颅内病变的组织学和分子诊断。Objective To explore the efficacy of Rosa robot-assisted stereotactic intracranial biopsy.Methods The clinical data of 33 patients with intracranial lesion who underwent Rosa robot-assisted stereotactic intracranial biopsy from October 2018 from August 2020.Results There was no navigation failure during the operation,and all procedures were completed successfully.Seven-six biopses were performed on these 33 patients,with no intracranial hemorrhage and epileptic seizures after the operation.The positive rate was 100%,including 21 patients with glioma,5 with diffuse large B-cell lymphoma,2 with vascular malformation,1 with metastatic adenoma,2 with germ cell tumor,1 with anaplastic meningioma,and 1 with inflammatory demyelination.Of 21 patients with glioma,IDH-1 mutation was detected in 6 patients(28.6%),and MGMT promoter methylation was detected in 16 patients(76.2%).The loss of 1p/19q heterozygosity was found in 1 patient with anaplastic oligodendroglioma.Conclusions Rosa robot-assisted stereotactic frameless biopsy is a relatively safe and feasible operation,which can be used for histological and molecular diagnosis of intracranial lesions.

关 键 词：颅内病变 Rosa机器人 立体定向活检术 

分 类 号：R739.41[医药卫生—肿瘤] R651.11[医药卫生—临床医学]