microRNAs影响急性髓系白血病细胞分化的研究进展  

Research progress of microRNAs affecting acute myeloid leukemic cell differentiation

作　　者：王洪涛 陈万灵 WANG Hongtao;CHEN Wanling(Department of Clinical Medicine,Xiamen Medical College,Xiamen,Fujian,361023,China;The Second Affiliated Hospital of Xiamen Medical College,Xiamen,Fujian,361021,China)

机构地区：[1]厦门医学院临床医学系,福建厦门361023 [2]厦门医学院附属第二医院,福建厦门361021

出　　处：《当代医学》2021年第24期190-194,共5页Contemporary Medicine

基　　金：厦门医学院大学生创新创业训练计划资助项目(201912631003);福建省卫生健康科研人才培养项目青年科研课题(2019-2-45);福建省中青年教师教育科研项目(JAT190835)。

摘　　要：急性髓系白血病(acute myelocyticleukemia,AML)是一类造血干祖细胞的恶性克隆性疾病,与造血细胞分化密切相关。microRNAs是一种在真核生物中被发现的小型的非编码RNA,控制多项参与造血干细胞的生成和分化及肿瘤发生的基因表达,影响AML细胞分化。本文旨在对影响AML细胞分化的microRNAs进行综述。Acute myelocytic leukemia(AML)is malignant clonal disease of hematopoietic stem and progenitor cells,which is closely related to the differentiation of hematopoietic cells.MicroRNAs is small non-coding RNA found in eukaryotes,which controls the expression of many genes in-volved in the generation and differentiation of hematopoietic stem cells and tumorigenesis,and affects the differentiation of AML cells.This article aims to review the microRNAs that affect the differentiation of AML cells.

关 键 词：MICRORNAS 急性白血病 细胞分化 

分 类 号：R733.71[医药卫生—肿瘤]