高血压与ccRCC发生及病理改变的相关性研究  

Correlation between hypertension and the risk of clear cell renal cell carcinoma and pathological variation

作　　者：周睿[1] 李阳[2] 肖海兵 朱劲松[1] 汪俊虎 Zhou Rui;Li Yang;Xiao Haibin(Dept of Urology,Anqing Municipal Hospital Affiliated Anhui Medical University,Anqing 246000;Dept of Pathology,Anqing Municipal Hospital Affiliated Anhui Medical University,Anqing 246000;Dept of Urology,The First Affiliated Hospital of Anhui Medical University,Hefei 230022)

机构地区：[1]安徽医科大学安庆附属医院泌尿外科,安庆246000 [2]安徽医科大学安庆附属医院病理科,安庆246000 [3]安徽医科大学第一附属医院泌尿外科,合肥230022 [4]安徽医科大学安庆附属医院体检中心,安庆246000

出　　处：《安徽医科大学学报》2021年第8期1281-1284,共4页Acta Universitatis Medicinalis Anhui

基　　金：国家自然科学基金(编号:81902584)。

摘　　要：目的分析高血压与肾透明细胞癌(ccRcc)发病风险及病理特征的相关性。方法回顾性分析201例ccRCC患者的相关临床资料,1005例在安庆附属医院体检中心体检的正常人群作为对照组。比较两组人群在代谢综合征、吸烟等资料的差异;应用Logistics多因素回归分析,分析高血压与肾癌的相关性,并将肾癌组分为合并高血压组(A组)与非高血压组(B组),分析相关的病理资料的差异。结果对照组与ccRCC组总胆固醇、三酰甘油、高密度脂蛋白、低密度脂蛋白、尿酸比较差异无统计学意义。2组的高血压、肥胖、糖尿病、吸烟人数占比进行比较(χ^(2)=109.318、4.949、4.142、15.589,P<0.05),差异有统计学意义。Logisitic回归分析提示高血压与肾癌发病风险呈正相关。A组与B组的腹主动脉的动脉斑块发生率、Furman核分级≤2级检出率、Ki67指数≤5%的检出率、微血管密度比较差异有统计学意义(P<0.05)。微血管侵犯在2组比较(χ^(2)=2.22,P=0.14)差异无统计学意义。结论在ccRCC患者中合并高血压的比例较正常人群发生率高。高血压可能参与ccRCC的发生及进展,在肾癌的高危人群中需要临床合理早期干预和预防高血压。Objective To investigate the correlation between hypertension and the risk and pathological changes of renal clear cell carcinoma.Methods The clinical data of 201 patients undergoing renal clear cell carcinoma surgery and renal pathology were retrospectively analyzed in this study.According to the ratio of age and sex,1005 normal people who underwent physical examination in the physical examination center of Anqing Municipal Hospital were used as the control group.The differences in metabolic syndrome,smoking were compared between the two groups.By using Logistics multi-factor regression analysis,the correlation between hypertension and renal cancer was analyzed,and the renal cancer group was divided into the hypertensive group(group A)and the non-hypertensive group(group B),and the differences of relevant pathological data were analyzed.Results There was no significant difference in total cholesterol,triglyceride,high-density lipoprotein(HDL),low-density lipoprotein(LDL)and uric acid between the two groups.Hypertension,smoking,diabetes and obesity prevalence in two groupswere compared(χ^(2)=109.318,4.949,4.142,15.589;P<0.05),and the differences were statistically significant.Logisitic regression analysis suggested that hypertension was positively correlated with the risk of renal cancer.There were statistical differences between the two groups in the incidence of arterial plaque in the abdominal aorta of the two groups,the incindence of clinical stage,Furman nuclear grade≤grade 2 detection rate,Ki67 index≤5%detection rate,microvascular density(P<0.05).There was statistically meaningless in microvascular invasion.Conclusion The incidence of hypertension in patients with renal clear cell carcinoma is higher than that in the normal population.Hypertension may be an associated factor involved in the development and progression of renal clear cell carcinoma.Early reasonable intervention and prevention of hypertension are recommended in the high-risk population of renal carcinoma.

关 键 词：ccRCC 高血压 病理特点 

分 类 号：R737.11[医药卫生—肿瘤]