抑郁症患者血清IL-6、IL-18、GFAP、Hcy水平与病情严重程度及认知功能的关系研究  

Study on the Relationship between Serum IL-6,IL-18,GFAP,Hcy Levels and Severity of Illness and Cognitive Function in Patients with Depression

作　　者：郭小兵[1,2] 丰雷 赵馨[1,2] 张国富[3] 王丽娜 GUO Xiao-bing;FENG Lei;ZHAO Xin;ZHANG Guo-fu;WANG Li-na(Department of Psychiatry,Beijing Anding Hospital Affiliated to Capital Medical University,Beijing,100088,China;Advanced Innovation Center for Human Brain Protection,Capital Medical University,Beijing,100070,China;Wuxi Mental Health Center Affiliated to Nanjing Medical University,Wuxi,Jiangsu,214002,China;Department of Psychiatry,The Second Affiliated Hospital of Xinxiang Medical College,Xinxiang,Henan,453002,China)

机构地区：[1]首都医科大学附属北京安定医院精神科,北京100088 [2]首都医科大学人脑保护高精尖创新中心,北京100070 [3]南京医科大学附属无锡精神卫生中心,江苏无锡214002 [4]新乡医学院第二附属医院精神科,河南新乡453002

出　　处：《现代生物医学进展》2021年第15期2872-2876,共5页Progress in Modern Biomedicine

基　　金：北京市自然科学基金项目(4182005)。

摘　　要：目的:探讨抑郁症患者血清白介素-6(IL-6)、白介素-18(IL-18)、胶质纤维蛋白(GFAP)、同型半胱氨酸(Hcy)水平与病情严重程度、认知功能的关系。方法:纳入首都医科大学附属北京安定医院、南京医科大学附属无锡精神卫生中心及新乡医学院第二附属医院2019年1月~2019年12月收治的抑郁症患者100例,根据17项汉密尔顿抑郁量表(HAMD-17)评分分成轻度组(n=42,HAMD-17评分为8~16分)、中度组(n=35,HAMD-17评分为17~23分)以及重度组(n=23,HAMD-17评分≥24分)。比较三组患者血清IL-6、IL-18、GFAP、Hcy水平。根据蒙特利尔认知评估量表(MoCA)评估结果分成认知障碍组(n=29)、非认知障碍组(n=71),比较两组血清IL-6、IL-18、GFAP、Hcy水平。经Pearson线性相关模型分析抑郁症患者血清IL-6、IL-18、GFAP、Hcy与HAMD-17评分、MoCA评分的相关性。结果:中、重度组的血清IL-6、IL-18、GFAP、Hcy及HAMD-17评分较轻度组明显升高,且重度组高于中度组(P<0.05)。认知障碍组血清IL-6、IL-18、GFAP、Hcy较非认知障碍组明显升高,延迟记忆、抽象思维、注意力、记忆力、视空间执行能力、语言流畅、定向力、命名评分及MoCA总分较非认知障碍组明显降低(P<0.05)。血清IL-6、IL-18、GFAP、Hcy与HAMD-17评分呈正相关(P<0.05),其与延迟记忆、抽象思维、注意力、记忆力、视空间执行能力、语言流畅、定向力评分及Mo CA总分呈负相关(P<0.05)。结论:血清IL-6、IL-18、GFAP、Hcy随抑郁症患者的抑郁程度加重而升高,且在有认知障碍的抑郁症患者中明显更高,上述四指标均与HAMD-17、MoCA评分具一定相关性,或可作为评估抑郁症患者病情的辅助指标。Objective: To explore the relationship between serum levels of interleukin-6(IL-6), interleukin-18(IL-18), glial fibrillary acidic protein(GFAP), homocysteine(Hcy), severity of illness and cognitive function in patients with depression. Methods: 100 cases of depression patients admitted to Beijing Anding Hospital Affiliated to Capital Medical University, Wuxi Mental Health Center Affiliated to Nanjing Medical University and The Second Affiliated Hospital of Xinxiang Medical College from January 2019 to December 2019 were included, According to the 17 Hamilton Depression Rating Scale(HAMD-17) scores, they were divided into mild group(n=42,HAMD-17 score of 8-16 points), moderate group(n=35, HAMD-17 score of 17-23 points) and severe group(n 23, HAMD-17 score ≥24 points). The serum levels of IL-6, IL-18, GFAP and Hcy were compared among the three groups. They were divided into cognitive impairment group(n=29) and non-cognitive impairment group(n=71) according to Montreal Cognitive Assessment Scale(MoCA) score results. The serum levels of IL-6, IL-18, GFAP and Hcy were compared between the two groups. The correlation between serum IL-6,IL-18, GFAP, Hcy and HAMD-17 score and MoCA score of depression patients were analyzed by Pearson linear correlation model.Results: Serum IL-6, IL-18, GFAP, Hcy and HAMD-17 scores of the moderate group and severe group were significantly higher than those of the mild group, and the severe group was higher than the moderate group(P<0.05). The levels of serum IL-6, IL-18, GFAP and Hcy in the cognitively impaired group were significantly higher than those in the non-cognitively impaired group, delayed memory, abstract thinking, attention, memory, visual space execution ability, language fluency, orientation, naming score and total score of MoCA were significantly lower than those of the non-cognitive impairment group(P<0.05). Serum IL-6, IL-18, GFAP, Hcy were positively correlated with HAMD-17 scores(P<0.05), and were negatively correlated with MoCA scores for delayed memory, abstract th

关 键 词：抑郁症 白介素-6 白介素-18 胶质纤维蛋白 同型半胱氨酸 认知功能 病情严重程度 

分 类 号：R749.06[医药卫生—神经病学与精神病学]