粪便中双歧杆菌和大肠杆菌含量对肝癌患者预后的预测价值分析  

Predictive Values of Bifidobacteria and E. coli in Feces on Prognosis of Patients with Hepatocelluar Carcinom

作　　者：薛飞 邵吉宝 胡金曹[3] 李杰[4] 顾明青 XUE Fei;SHAO Ji-bao;HU Jin-cao;LI Jie;GU Ming-qing(Department of Laboratory Medicine,Affiliated Hospital of Jiangnan University,Wuxi,Jiangsu,214062,China;Department of Laboratory Medicine,The Affiliated Brain Hospital of Nanjing Medical University,Nanjing,Jiangsu,210029,China;Department of Laboratory Medicine,Nanjing Drum Tower Hospital,The Affiliated Hospital of Nanjing University Medical School,Nanjing,Jiangsu,210000,China;Department of Laboratory Medicine,Pukou Branch of Jiangsu Province People's Hospital,Nanjing,Jiangsu,211800,China)

机构地区：[1]江南大学附属医院检验科,江苏无锡214062 [2]南京医科大学附属脑科医院检验科,江苏南京210029 [3]南京大学医学院附属鼓楼医院检验科,江苏南京210000 [4]江苏省人民医院浦口分院检验科,江苏南京211800

出　　处：《现代生物医学进展》2021年第14期2764-2767,共4页Progress in Modern Biomedicine

基　　金：江苏省自然科学基金项目(BK20160195)。

摘　　要：目的:探讨与分析粪便中双歧杆菌和大肠杆菌含量对肝癌患者预后的预测价值。方法:研究时间为2016年12月到2019年12月,采用回顾性研究方法,选择在本院重症监护病房(Intensive Care Unit,ICU)诊治的肝癌患者78例作为研究对象,检测粪便中双歧杆菌和大肠杆菌含量,调查患者的预后并进行预测价值分析。结果:在78例患者中,死亡18例,死亡率为23.1%。存活组与死亡组的性别、年龄、体重指数、白细胞(white blood cell,WBC)、血小板(Platelets,PLT)计数计数等对比差异无统计学意义(P>0.05),两组的急性生理学及慢性健康状况评分系统(acute physiology andchronic health evaluation scoring system,APACHEⅡ)评分、临床分期等对比差异有统计学意义(P<0.05),死亡组的血清甲胎蛋白(α-fetoprotein,AFP)值显著高于存活组(P<0.05)。死亡组的双歧杆菌含量与双歧杆菌/大肠杆菌比值低于存活组,大肠杆菌含量高于存活组,对比差异都有统计学意义(P<0.05)。直线相关分析显示患者预后死亡与双歧杆菌/大肠杆菌比值、AFP、APACHEⅡ评分、临床分期有相关性(P<0.05)。双歧杆菌/大肠杆菌比值对肝癌患者预后死亡的预测ROC曲线下总面积为0.865。结论:肝癌患者预后死亡患者多伴随有粪便中菌群失衡状况,粪便中双歧杆菌和大肠杆菌含量能很好预测肝癌患者的预后。Objective: To explore and analysis the predictive value of bifidobacteria and E. coli contents in feces on the prognosis of patients with hepatocelluar carcinoma. Methods: The study period were from December 2016 to December 2019. Used the retrospective research methods, 78 cases of patients with hepatocelluar carcinom diagnosed and treated in the intensive care unit(ICU) of our hospital were selected as the research objects, all cases were to detect bifidobacteria and E. coli contents in feces. and were to investigated the prognosis of patients and performed the predictive value analysis. Results: There were 18 cases were died in the 78 cases and the mortality rate were 23.1 %. There were no significant differences in gender, age, body mass index, WBC and PLT counts compared between the survival group and the death group(P>0.05), and there were statistically significant differences in the APACHE Ⅱscore and clinical stage compared between the two groups(P<0.05), The serum AFP values in the death group was significantly higher than that in the survival group(P<0.05). The content of Bifidobacterium and the ratio of Bifidobacterium/E. Coli in the death group were lower than those in the survival group, and the content of E. coli were higher than that in the survival group, and compared the differences were statistically significant(P<0.05). Linear correlation analysis showed that the prognosis of patients was correlated with the bifidobacterium/E. Coli ratio, AFP, APACHE Ⅱ score, and clinical stage(P<0.05). The total area under the predicted ROC curve of the bifidobacterium/E. Coli ratio for the prognosis of liver cancer patients were 0.865. Conclusion: The prognosis of patients with hepatocelluar carcinoma are mostly associated with the imbalance of bacterial flora in feces. The content of bifidobacteria and E. coli in stool can predict the prognosis of patients with hepatocelluar carcinoma.

关 键 词：肝癌 预后 粪便 双歧杆菌 大肠杆菌 

分 类 号：R735.7[医药卫生—肿瘤]