绝经后高危型HPV感染女性阴道微生态环境变化特征  

The change characteristics of the vaginal microecological environment of postmenopausal women with high risk-human papilloma virus infection

作　　者：张艳 ZHANG Yan(The First People's Hospital of Wuyi, Jinhua, Zhejiang Province, 321200)

机构地区：[1]浙江省金华市武义县第一人民医院,321200

出　　处：《中国计划生育学杂志》2021年第7期1418-1422,共5页Chinese Journal of Family Planning

摘　　要：目的:分析绝经后高危型人乳头状瘤病毒(HR-HPV)感染女性阴道微生态环境特点。方法:选择2017年1月-2019年12月本院HR-HPV DNA检测阳性及阴性绝经后女性和阳性育龄期女性,根据活检病理、HPV感染类别分析阴道微生态形态学及功能学指标的变化。结果:绝经后HPV阳性组PH值≥5.0、清洁度Ⅲ~Ⅳ、细菌性阴道病(BV)、过氧化氢(H_(2)O_(2))阳性、唾液酸苷酶(SNA)阳性、β-葡萄糖醛酸酶(GUS)阳性比例高于绝经后HPV阴性组,但低于育龄期HPV阳性组(均P<0.05);绝经后HPV阳性组VVC、TV、LE阳性、NAG阳性比例低于育龄期HPV阳性组(P<0.05),但与绝经后HPV阴性组无差异(P>0.05)。活检病理≥HSIL组PH≥5.0、清洁度Ⅲ~Ⅳ、BV、H_(2)O_(2)阳性、SNA阳性比例高于活检病理<LSIL(P<0.05),但VVC、TV、LE阳性、NAG阳性、GUS阳性比例无差异(P>0.05);HPV多重感染妇女PH≥5.0、清洁度ⅡI~IV、BV、H_(2)O_(2)阳性、SNA阳性、GUS阳性比例高于HPV单一感染妇女(P<0.05),但VVC、TV、LE阳性、NAG阳性比例无差异(P>0.05)。BV、H_(2)O_(2)阳性、SNA阳性是绝经后女性HPV多重感染的独立危险因素(P<0.05)。结论:绝经后HR-HPV感染女性阴道微生态异常特点异于育龄期女性,可能导致宫颈高级别病变及HPV多重感染发生。Objective:To analyze the characteristics of the vaginal microecological environment of postmenopausal women with high risk-human papilloma virus(HR-HPV)infection.Methods:From January 2017 to December 2019,the postmenopausal women with HR-HPV infection were selected in group A,the child-bearing period women with HR-HPV infection were selected in group B,and the postmenopausal women without HR-HPV infection were selected in group C.The changes of the indexes on vaginal microecological morphology and functionality of the women in the three groups were analyzed according to their biopsy pathology and HPV infection types.Results:The rates of PH value≥5.0,vaginal cleanliness III-IV,and the positive ratios of BV,H_(2)O_(2),SNA,and GUS of the women in group A were significant higher than those of the women in group C,but those of the women in group C were significant lower than those of the women in group B(all P<0.05).The positive ratios of VVC,TV,LE,and NAG of the women in group A were significant lower than those of the women in group B(P<0.05),but there were no significant differences in the positive ratios of VVC,TV,LE,and NAG of the women between group B and group C(P>0.05).The ratios of PH≥5.0,vaginal cleanliness III-IV,BV,positive H_(2)O_(2),and positive SNA of the women with biopsy pathology≥HSIL were significant higher than those of the women with biopsy pathology<LSIL(P<0.05),but there were no significant differences in the positive ratios of VVC,TV,LE,NAG,and GUS between the women with biopsy pathology≥HSIL and the women with biopsy pathology<LSIL(P>0.05).The ratios of PH≥5.0,vaginal cleanliness III-IV,BV,positive H_(2)O_(2),positive SNA,and positive GUS of the women with multiple HPV infections were significant higher than those of the women with single HPV infection(P<0.05),but there were no significant differences in the positive ratios of VVC,TV,LE,and NAG between the women with multiple HPV infections and the women with single HPV infection(P>0.05).Positive BV,H_(2)O_(2),and SNA were the indepe

关 键 词：绝经 宫颈病变 人乳头瘤病毒 阴道微生态 危险因素 

分 类 号：R73[医药卫生—肿瘤]