The Influence of Sperm DNA Damage and Semen Homocysteine on Male Infertility  

作　　者：Kang-Sheng Liu Feng Pan Ya-Jun Chen Xiao-Dong Mao 

机构地区：[1]Department of Clinical Laboratory,Nanjing Obstetrics and Gynecology Hospital Affiliated to Nanjing Medical University,Nanjing Maternity and Child Health Care Hospital,Nanjing,Jiangsu 210029,China [2]Department of Andrology,State Key Laboratory of Reproductive Medicine,Nanjing Obstetrics and Gynecology Hospital Affiliated to Nanjing Medical University,Nanjing,Jiangsu 210029,China [3]Department of Endocrinology,Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Nanjing University of Chinese Medicine,Nanjing,Jiangsu 210028,China

出　　处：《Reproductive and Developmental Medicine》2017年第4期228-232,共5页生殖与发育医学（英文版）

摘　　要：Background:To explore the relationship of sperm DNA fragmentation index(DFI),serum and seminal plasma homocysteine(Hcy),and semen parameters in patients with severe spermatogenetic dysfunction.Methods:A total of 77 infertile males treated in our hospital for severe spermatogenetic dysfunction from January 2016 to November 2017 were recruited.The involved patients were divided into two groups:oligozoospermia(SOM group,35 cases)and asthenozoospermia(OAT group,42 cases).The control group(NM group)contained 31 healthy males without reproductive dysfunctions.All the participants involved were tested in the items below:spermatozoa parameters,spermatozoa DFI,serum Hcy level and seminal plasma Hcy level,concentration of seminal plasma malondialdehyde(MDA),and total antioxidant capacity(TAC).Results:Between the SOM group and NM group,there were significantly difference in sperm concentration,motility and vitality,concentration of MDA,and TAC.The spermatozoa DFI and Hcy levels in SOM group were significantly higher than those of the NM group.Sperm DFI was positively correlated with serum Hcy level(r=0.083,P<0.05).Serum Hcy level was negatively correlated with sperm concentration(r=−0.186,P<0.05)and sperm vitality(r=−0.216,P<0.05).The serum Hcy level was not correlated with sperm Hcy level(r=0.103,P>0.05).Conclusions:The elevated Hcy level and spermatozoa DFI may be important factors of the severe spermatogenetic dysfunction,which can be used as semen index to evaluate sperm quality and male fertility.

关 键 词：DNA Fragmentation Index HOMOCYSTEINE Male Infertility Routine Spermatozoa Parameters 

分 类 号：R698.2[医药卫生—泌尿科学]