血清circNRIP1表达在胃癌诊疗中的临床意义  

Clinical Significance of Serum CircNRIP1 Expression in Diagnosis and Treatment of Gastric Cancer

作　　者：陈婧 张荣 王浩斌 邱昌伟 CHEN Jing;ZHANG Rong;WANG Haobin;QIU Changwei(Department of Gastroenterology,Dujiangyan People’s Hospital(Dujiangyan Medical Center),Dujiangyan,Sichuan Province,611830;Department of General Surgery,the Third People’s Hospital of Chengdu,Chengdu)

机构地区：[1]都江堰市人民医院(都江堰市医疗中心)消化内科,611830 [2]成都市第三人民医院普外科

出　　处：《胃肠病学》2021年第1期39-42,共4页Chinese Journal of Gastroenterology

基　　金：国家自然科学基金(81702963)。

摘　　要：背景:环状RNA(circRNA)与恶性肿瘤的发生、发展存在关联,最近研究表明部分circRNA在胃癌的早期诊断、治疗靶点筛选和预后判断中具有重要的临床转化价值。目的:探讨circNRIP1在胃癌患者血清中的表达及其对胃癌诊断、治疗和预后的临床意义。方法:选取2016年9月—2019年9月都江堰市人民医院收治的76例病理确诊的胃癌患者,以63名健康体检者设置为健康对照组。运用实时荧光定量PCR法检测血清circNRIP1表达,并分析胃癌患者血清circNRIP1表达与临床病理特征的关系,ROC曲线分析circNRIP1的诊断效能。结果:胃癌患者血清circNRIP1表达显著高于健康对照组(P<0.01)。胃癌circNRIP1表达与肿瘤细胞分化程度、浸润深度、淋巴结转移和TNM分期具有相关性(P<0.05)。胃癌患者术后血清circNRIP1表达较术前显著降低(P<0.05)。术后随访2年发现,胃癌存活组血清circNRIP1表达明显低于死亡组(P<0.05)。ROC曲线显示血清circNRIP1表达诊断胃癌的敏感性为88.9%,特异性为88.2%,AUC为0.876。结论:检测胃癌患者血清circNRIP1表达有利于胃癌的早期诊断以及对胃癌患者治疗效果和预后的评估。Background:Circular RNAs(circRNAs)is correlated with the development and progression of malignant tumor.Recent studies have shown the potentials of some circRNAs in the early diagnosis,screening of therapeutic targets and prognostic judgment of gastric cancer.Aims:To investigate the serum circNRIP1 expression and its clinical significance in the diagnosis,treatment and prediction of prognosis of gastric cancer.Methods:A total of 76 gastric cancer patients diagnosed by pathology from September 2016 to September 2019 at Dujiangyan People’s Hospital were enrolled,and 63 healthy individuals were served as controls.Serum circNRIP1 expression was detected by real time fluorescent quantitative PCR,and its correlation with clinicopathological features was analyzed.ROC curve was used to analyze the diagnostic efficiency.Results:Serum circNRIP1 expression in gastric cancer group was significantly higher than that in healthy control group(P<0.01).The circNRIP1 expression in gastric cancer patients was significantly correlated with the differentiation of tumor cells,depth of infiltration,lymph node metastasis and TNM stage(P<0.05).Serum circNRIP1 expression in gastric cancer patients after operative treatment was significantly lower than that before treatment(P<0.05).After 2 years follow-up,serum circNRIP1 expression in survival group was significantly lower than that in death group(P<0.05).ROC curve analysis showed that the sensitivity of serum circNRIP1 expression for gastric cancer was 88.9%,the specificity was 88.2%,and AUC was 0.876.Conclusions:Detecting serum circNRIP1 expression has significant value in the early diagnosis and evaluation of treatment and prediction of prognosis of gastric cancer.

关 键 词：胃肿瘤 环状RNAs CircNRIP1 诊断 预后 

分 类 号：R735.2[医药卫生—肿瘤]