联合检测IL-6 FIB CA125及HE4对早期卵巢癌的诊断价值  

Diagnostic value of combined detection of IL-6,FIB,CA125,and HE4 in early ovarian cancer

作　　者：魏春丽[1] 李婷 王永红 夏江[4] 王伍姣[1] WEI Chun-Li;LI Ting;WANG Yong-Hong(Huazhong University of Science and Technology Hospital,Wuhan,Hubei 425300,China)

机构地区：[1]华中科技大学医院,湖北武汉425300 [2]南华大学附属第二医院,湖南衡阳421000 [3]武汉理工大学医院,湖北武汉430070 [4]武汉市疾病预防控制中心,湖北武汉430022

出　　处：《中国妇幼保健》2021年第16期3666-3669,共4页Maternal and Child Health Care of China

基　　金：湖南省教育厅高校科研经费项目(15C1211)。

摘　　要：目的分析联合检测白细胞介素-6(IL-6)、纤维蛋白原(FIB)、糖类抗原125(CA125)及人附睾蛋白4(HE4)对早期卵巢癌的诊断价值。方法选择2019年1月-2020年1月收治的120例卵巢肿瘤患者为研究对象,包括60例卵巢癌患者(卵巢癌组)和60例良性卵巢肿瘤患者(良性卵巢肿瘤组),另选取同期进行健康体检的60例女性为对照组。抽取3组受试者空腹静脉血5 ml,检测IL-6、HE4、FIB及CA125水平,分析IL-6、HE4、FIB及CA125对卵巢癌的早期诊断价值。结果卵巢癌组IL-6、HE4、FIB及CA125水平分别为(271.61±32.10)pg/ml、(121.25±22.63)pmol/L、(4.89±0.81)g/L及(59.33±7.65)kU/ml;良性卵巢肿瘤组IL-6、HE4、FIB及CA125水平分别为(136.25±21.23)pg/ml、(61.12±15.51)pmol/L、(3.25±0.51)g/L及(31.21±5.36)kU/ml;对照组IL-6、HE4、FIB及CA125水平分别为(92.12±17.66)pg/ml、(35.59±7.68)pmol/L、(2.86±0.37)g/L及(16.68±2.77)kU/ml。3组受试者IL-6、HE4、FIB及CA125水平比较差异均有统计学意义(F=878.192,P<0.001;F=428.937,P<0.001;F=198.346,P<0.001;F=891.512,P<0.001)。Ⅰ期卵巢癌患者IL-6、HE4、FIB及CA125水平分别为(261.60±13.59)pg/ml、(115.11±18.61)pmol/L、(4.10±0.70)g/L及(46.56±5.51)kU/ml;Ⅱ期卵巢癌患者IL-6、HE4、FIB及CA125水平分别为(286.23±36.51)pg/ml、(137.33±21.27)pmol/L、(4.52±0.81)g/L及(67.25±6.35)kU/ml。Ⅰ期卵巢癌患者和Ⅱ期卵巢癌患者IL-6、HE4、FIB及CA125水平比较差异均有统计学意义(t=3.549,P=0.001;t=4.317,P<0.001;t=2.159,P=0.035;t=13.515,P<0.001)。IL-6+FIB+CA125+HE4联合检测诊断卵巢癌的效能最高,灵敏度为96.67%,特异度为76.67%。结论 IL-6、HE4、FIB及CA125联合检测可提高卵巢癌的早期诊断效能,对卵巢癌的早期诊断和治疗有重要参考价值。Objective To analyze the diagnostic value of combined detection of interleukin-6(IL-6),fibrinogen(FIB),carbohydrate antigen 125(CA125),and human epididymis protein(HE4) in early ovarian cancer.Methods From January 2019 to January 2020,120 patients with ovarian tumor were selected as study object,60 patients with ovarian cancer(ovarian cancer group) and 60 patients with benign ovarian tumor(benign ovarian tumor group) were included,60 women receiving healthy physical examination were selected as control group. Fasting venous blood samples(5 ml) were obtained in the three groups,the levels of IL-6,HE4,FIB,and CA125 were detected,the early diagnostic value of IL-6,HE4,FIB,and CA125 for ovarian cancer was analyzed.Results The levels of IL-6,HE4,FIB,and CA125 in ovarian cancer group were(271.61±32.10) pg/ml,(121.25±22.63) pmol/L,(4.89±0.81) g/L,and(59.33±7.65) kU/ml,respectively;the levels of IL-6,HE4,FIB,and CA125 in benign ovarian tumor group were(136.25±21.23) pg/ml,(61.12±15.51) pmol/L,(3.25±0.51) g/L,and(31.21±5.36) kU/ml,respectively;the levels of IL-6,HE4,FIB,and CA125 in control group were(92.12±17.66) pg/ml,(35.59±7.68) pmol/L,(2.86±0.37) g/L,and(16.68±2.77) kU/ml,respectively. There were statistically significant differences in the levels of IL-6,HE4,FIB,and CA125 among the three groups(F=878.192,P<0.001;F=428.937,P<0.001;F=198.346,P<0.001;F=891.512,P<0.001). The levels of IL-6,HE4,FIB,and CA125 in stage Ⅰ ovarian cancer group were(261.60±13.59) pg/ml,(115.11±18.61) pmol/L,(4.10±0.70) g/L,and(46.56±5.51) kU/ml,respectively;the levels of IL-6,HE4,FIB,and CA125 in stage Ⅱ ovarian cancer group were(286.23±36.51) pg/ml,(137.33±21.27) pmol/L,(4.52±0.81) g/L,and(67.25±6.35) kU/ml,respectively. There were statistically significant differences in the levels of IL-6,HE4,FIB,and CA125 between stage Ⅰ ovarian cancer group and stage Ⅱ ovarian cancer group(t=3.549,P=0.001;t=4.317,P<0.001;t=2.159,P=0.035;t=13.515,P<0.001). The diagnostic efficiency of IL-6+FIB+CA125+HE4 for ovarian cancer was t

关 键 词：白细胞介素-6 纤维蛋白原 糖类抗原125 人附睾蛋白4 早期卵巢癌 诊断 

分 类 号：R737.31[医药卫生—肿瘤]