腹腔镜下大肠癌根治术患者术后生存质量的影响因素分析  

Analysis of influencing factors on postoperative quality of life of patients undergoing laparoscopic radical resection of colorectal cancer

作　　者：任继兵[1] 陈梦琳[1] REN Ji-bing;CHEN Meng-lin(The Second Department of General Surgery,Songzi People′s Hospital,Hubei Province,Songzi434200,China)

机构地区：[1]湖北省松滋市人民医院普外二科,湖北松滋434200

出　　处：《中国当代医药》2021年第23期117-119,123,共4页China Modern Medicine

摘　　要：目的探讨腹腔镜下大肠癌根治术患者术后生存质量影响因素。方法选择2017年9月—2019年9月松滋市人民医院拟行腹腔镜根治术的103例大肠癌患者作为研究对象。术后采用电话、门诊复查等方式随访,随访12个月评价患者生存质量情况,采用Karnofsky功能状态(KPS)评分标准评价生存质量。采用多因素Logistic回归分析影响术后生存质量的独立危险因素。结果经单因素分析显示,不同性别、家族史、TNM分期、合并基础疾病、术前癌胚抗原(CEA)、术前糖类抗原19-9(CA19-9)、浸润深度和术中出血量的KPS评分比较,差异无统计学意义(P>0.05);年龄>60岁患者KPS评分低于年龄≤60岁患者,低分化患者KPS评分低于高、中分化患者,肿瘤直径>5 cm患者KPS评分低于肿瘤直径≤5 cm的患者,术前肠梗阻患者KPS评分低于无肠梗阻的患者,淋巴结转移患者KPS评分低于无淋巴结转移的患者,差异均有统计学意义(P<0.05)。单因素分析差异有统计学意义的经多因素Logistic回归分析,年龄、分化程度、肿瘤直径、术前肠梗阻和淋巴结转移为影响术后生存质量独立危险因素(P<0.05)。结论腹腔镜下大肠癌根治术患者术后生存质量影响因素中,年龄、分化程度、肿瘤直径、术前肠梗阻和淋巴结转移为影响术后生存质量独立危险因素。Objective To explore the influencing factors of quality of life in patients with colorectal cancer after laparoscopic radical resection.Methods A Total of 103 patients with colorectal cancer undergoing laparoscopic radical operation in Songzi People′s Hospital from September 2017 to September 2019 were selected as the research objects.The patients were followed up for 12 months by telephone and outpatient reexamination.The quality of life was evaluated by Karnofsky Performamce Status(KPS)score.Multivariate Logistic regression analysis was used to analyze the risk factors of postoperative quality of life.Results Univariate analysis showed that there were no significant differences in KPS scores of gender,family history,TNM stage,basic diseases,preoperative carcino-embryonic antigen(CEA),preoperative carbohydrate antigen 19-9(CA19-9),depth of invasion and intraoperative blood loss(P>0.05);KPS score of patients aged>60 were lower than those of patients≤60 years old,KPS scores of patients with low differentiation were lower than those of patients with high and moderate differentiation,and KPS scores of patients with tumor diameter>5 cm was lower those of patients with tumor diameter<5 cm,the KPS scores of patients with intestinal obstruction were lower than those without intestinal obstruction,and the KPS score of patients with lymph node metastasis were lower than those without lymph node metastasis(P<0.05).Multivariate Logistic regression analysis showed that age,differentiation degree,tumor diameter,preoperative intestinal obstruction and lymph node metastasis were independent risk factors for postoperative quality of life(P<0.05).Conclusion Age,differentiation degree,tumor diameter,preoperative intestinal obstruction and lymph node metastasis are independent risk factors for postoperative quality of life in patients with laparoscopic radical resection of colorectal cancer.

关 键 词：腹腔镜下大肠癌根治术 术后生存质量 影响因素 

分 类 号：R735.34[医药卫生—肿瘤]