曲克芦丁联合拜阿司匹林治疗老年伴大脑中动脉高密度征急性脑梗死静脉溶栓患者的疗效  

Efficacy of troxerutin and Bayaspirin combined with intravenous thrombolysis in the treatment of elderly ACI patients with HMCAS

作　　者：张云东 朱德才 赵彪 毛乐岚 Zhang Yundong;Zhu Decai;Zhao Biao;Mao Lelan(Emergency Department,Bozhou Hospital Affiliated to Anhui Medical University,Bozhou,Anhui,236800,P.R.China;Department of Endocrinology,Ninth People's Hospital Affiliated to School of Medical of Shanghai Jiaotong University,Shanghai,200011,P.R.China)

机构地区：[1]安徽医科大学附属亳州医院急诊科,安徽亳州236800 [2]上海交通大学医学院附属第九人民医院内分泌科,上海200011

出　　处：《老年医学与保健》2021年第4期790-793,共4页Geriatrics & Health Care

摘　　要：目的研究曲克芦丁联合拜阿司匹林治疗老年伴大脑中动脉高密度征(HMCAS)的急性脑梗死(ACI)静脉溶栓患者的疗效,为治疗该病提供方法。方法选取2018年1月-2020年1月安徽医科大学附属亳州医院收治的102例伴HMCAS的急性脑梗死患者,随机分为观察组(n=51)和对照组(n=51)。2组均进行静脉溶栓治疗,对照组在此基础上给予拜阿司匹林,观察组在与对照组相同治疗的基础上给予注射用曲克芦丁。观察并比较2组患者干预前后的Barthel评定量表(BI)评分、脑卒中量表(NIHSS)评分、血清超敏C反应蛋白(hs-CRP)与白介素6(IL-6)水平;评估并比较2组患者干预后的并发症发生率和治疗总有效率。结果观察组治疗总有效率明显高于对照组(P<0.05)。干预前,2组患者NIHSS评分、BI评分、hs-CRP和IL-6相比差异无统计学意义(P>0.05);干预后,2组患者BI评分均显著高于同组干预前(P<0.05),2组NIHSS评分、hs-CRP和IL-6水平较同组干预前显著下降(P<0.05),观察组BI评分明显高于对照组(P<0.05),观察组NIHSS评分、hs-CRP和IL-6均明显低于对照组(P<0.005)。2组患者并发症总发生率差异无统计学意义(P>0.05)。结论曲克芦丁联合拜阿司匹林治疗老年伴HMCAS急性脑梗死静脉溶栓患者的疗效较好,能有效改善患者的神经功能、日常生活能力和炎症状态,安全性较好。Objective To study the efficacy of troxerutin and Bayaspirin combined with intravenous thrombolysis in the treatment of elderly patients with acute cerebral infarction(ACI)complicated with hyperdense middle cerebral artery sign(HMCAS),and provide a method for the treatment of the disease.Methods 102 elderly ACI patients with HMCAS treated in the Bozhou Hospital Affiliated to Anhui Medical University from January 2018 to January 2020 were selected and randomly divided into observation group(n=51)and control group(n=51).Both groups were treated with intravenous thrombolysis.The control group was given Bayaspirin on this basis,and the observation group was given troxerutin for injection on the basis of the same treatment as the control group.The Barthel Rating Scale(BI)score,stroke scale(NIHSS)score,serum high-sensitivity C-reactive protein(hs-CRP)and interleukin-6(IL-6)levels were compared between the two groups before and after the treatment.The incidence of complications and the total effective rate were evaluated and compared between the two groups.Results The total effective rate of the observation group was significantly higher than that of the control group(P<0.05).Before the treatment,there was no significant difference in NIHSS score,BI score,hs-CRP and IL-6 levels between the two groups(P>0.05).After the treatment,the BI score of the two groups was significantly higher than that of the same group before the treatment(P<0.05),and the NIHSS score,hs-CRP and IL-6 levels of the two groups were significantly lower than those of the same group before the treatment(P<0.05),and the BI score of the observation group was significantly higher than that of the control group,the NIHSS score,hs-CRP and IL-6 levels were significantly lower than those of the control group(P<0.05).There was no significant difference in the total incidence of complications between the two groups(P>0.05).Conclusion The efficacy of troxerutin and Bayaspirin combined with intravenous thrombolysis in the treatment of elderly ACI patients with H

关 键 词：老年 大脑中动脉高密度征 急性脑梗死 曲克芦丁 拜阿司匹林 静脉溶栓 疗效 

分 类 号：R743.3[医药卫生—神经病学与精神病学]