泵注与静滴生长抑素治疗老年急性胰腺炎的效果对比分析  

Comparative analysis of the effects of pump injection and intravenous drip of somatostatin in the treatment of acute pancreatitis in the elderly

作　　者：张世巧[1] 姚波[1] 郭明松 谢亮[1] Zhang Shiqiao;Yao Bo;Guo Mingsong;Xie Liang(Department of Hepatobiliary Surgery,Sixth People's Hospital of Chengdu City,Chengdu,Sichuan,610051,P.R.China)

机构地区：[1]成都市第六人民医院肝胆外科,四川成都610051

出　　处：《老年医学与保健》2021年第4期847-850,859,共5页Geriatrics & Health Care

基　　金：四川省医学科研青年创新课题(Ql7010)。

摘　　要：目的对比观察泵注生长抑素与静滴生长抑素治疗老年急性胰腺炎(AP)的临床效果,为临床优选生长抑素治疗老年AP的输注方式提供依据。方法选择2018年11月-2020年11月在成都市第六人民医院接受住院治疗的老年AP患者184例,根据数字表法随机分为观察组(n=92)和对照组(n=92)。2组均给予生长抑素治疗,观察组患者采取微量输液持续泵注生长抑素,对照组采取常规静脉滴注生长抑素。观察并比较2组患者治疗前后临床症状改善情况、血清炎症因子水平、氧化应激水平、疗效和治疗不良反应情况。结果治疗后,观察组患者腹痛消失时间、血清淀粉酶以及进食情况恢复正常时间均显著少于对照组(P<0.05);2组患者血清炎症因子水平和氧化应激因子水平均显著低于同组治疗前(P<0.05),且观察组血清炎症因子水平和氧化应激因子水平显著低于对照组(P<0.05);2组患者治疗有效率差异无统计学意义(P>0.05);观察组患者治疗不良反应发生率显著低于对照组(P<0.05)。结论与静脉滴注相比,通过泵注生长抑素治疗老年AP的优势更大,可更精确地给药,促进患者临床症状迅速恢复,缩短病程,降低炎症程度,提高用药安全性。Objective To compare the effects of pump injection and intravenous drip of somatostatin in the treatment of acute pancreatitis(AP)in the elderly,so as to provide basis for the clinical optimization of somatostatin infusion in the treatment of AP in the elderly.Methods 184 elderly AP patients who were hospitalized in the Sixth People’s Hospital of Chengdu City from November 2018 to November 2020 were selected and randomly divided into observation group(n=92)and control group(n=92)according to the number table method.Both groups were treated with somatostatin,in which the observation group were treated with micro-infusion and continuous pump injection of somatostatin,and the control group were treated with routine intravenous drip of somatostatin.The improvement of clinical symptoms,level of serum inflammatory factors,level of oxidative stress,curative effect and adverse reactions were observed and compared between the two groups before and after treatment.Results After treatment,the disappearance time of abdominal pain,the recovery time of serum amylase and food intake of the observation group were significantly shorter than those of the control group(P<0.05).The levels of serum inflammatory factors and oxidative stress factors of the two groups were significantly lower than those of the same group before treatment(P<0.05),and the levels of the above indexes of the observation group were significantly lower than those of the control group(P<0.05).There was no significant difference in the effective rate of the treatment between the two groups(P>0.05).The incidence of adverse reactions in the observation group was significantly lower than that in the control group(P<0.05).Conclusion Compared with intravenous drip,pump injection of somatostatin has greater advantages in the treatment of AP in the elderly.It can be administered more accurately,promote the rapid recovery of clinical symptoms,shorten the course of disease,reduce the degree of inflammation and improve the safety of medication.

关 键 词：老年 生长抑素 急性胰腺炎 泵注 静滴 临床疗效 血清炎症因子 

分 类 号：R576[医药卫生—消化系统]