复方西羚解毒胶囊中角类药材的质谱法定性鉴别  

Qualitative identification of horns in Compound Xiling Jiedu Capsules by mass spectrometry

作　　者：王玉团 张海莲 陈晓 WANG Yutuan;ZHANG Hailian;CHEN Xiao(Shandong Institute for Food and Drug Control,Shandong Research Center of Engineering and Technology for Safety Inspection of Food and Drug,Jinan 250101,China;Heze Municipal Hospital,Heze 274031,China)

机构地区：[1]山东省食品药品检验研究院山东省食品药品安全检测工程技术研究中心,济南250101 [2]菏泽市立医院,山东菏泽274031

出　　处：《中国药品标准》2021年第4期337-340,共4页Drug Standards of China

摘　　要：目的:建立复方西羚解毒胶囊中角类药材的质谱定性检测方法,为提高相关药品的质量控制水平提供参考。方法:采用色谱柱ACQUITY UPLC BEH C 18(2.1 mm×50 mm,1.7μm),流速0.3 mL·min^(-1),梯度洗脱,电喷雾正离子模式,多反应监测,选择m/z(三电荷)697.66→1021.48、697.66→1181.49作为羚羊角的检测离子对,选择m/z(三电荷)715.33→910.52、715.33→572.28作为水牛角的检测离子对。结果:选择的离子对能够检出并区分目标角类药材,相应的阴性均无干扰。结论:建立的定性检测方法准确、可靠,能够对复方西羚解毒胶囊中羚羊角和水牛角浓缩粉进行鉴别,该研究对相关药品的标准提高及质量控制具有较高的参考价值。Objective:To establish a method for identification of horns in Compound Xiling Jiedu Capsules by mass spectrometry and to provide reference for improving the quality control of related drugs.Methods:The test was performed in ACQUITY UPLC BEH C 18 column(2.1 mm×50 mm,1.7μm)under the gradient elution.The flow rate was 0.3 mL·min^(-1) with gradient elution,electrospray ionization(ESI+)and multiple reaction monitoring(MRM)were carried out.The m/z(three charges)697.66→1021.48 and 697.66→1181.49 were selected as ion pairs for antelope horn,m/z(three charges)715.33→910.52 and 715.33→572.28 were selected as ion pairs for detection of buffalo horn.Results:The selected ion pairs could detect and distinguish the target angular,and the corresponding negative samples had no interference.Conclusions:The established qualitative method is accurate and reliable.It can accurately identify concentrated power of antelope horn and buffalo horn in Compound Xiling Jiedu Capsules.This study provides the good reference for improving the specifications and quality control of related drugs.

关 键 词：羚羊角 水牛角 质谱 鉴别 

分 类 号：R921.2[医药卫生—药学]