Sources, Toxicity and Detection Techniques of Semicarbazide: A Review  

作　　者：TIAN Xiuhui LI Huanjun HAN Dianfeng WEN Fenggong LIU Huan LIU Ge PENG Kaixiu GONG Xianghong LIU Xin WANG Weiyun YU Haixia XU Yingjiang 

机构地区：[1]Shandong Marine Resource and Environment Research Institute,Shandong Key Laboratory of Marine Ecological Restoration,Yantai 264006,China [2]College of Food Science and Technology,Shanghai Ocean University,Shanghai 201306,China [3]Ocean College,Zhejiang University,Zhoushan 316021,China [4]Chengyang Branch,Qindao Municipal Bureau of Ecology and Environment,Qindao 266000,China

出　　处：《Journal of Ocean University of China》2021年第5期1263-1275,共13页中国海洋大学学报（英文版）

基　　金：The work was supported by the National Key R&D Program of China(No.2017YFC1600702);the Key Lab of Marine Bioactive Substance and Modern Analytical Technique,SOA(No.MBSMAT-2019-04);the Modern Agro-Industry Technology Research System in Shandong Pro-vince(No.SDAIT-26-05);the National Natural Science Foundation of China(No.31901787).

摘　　要：Semicarbazide has become an important pollutant in the environment,but there was no comprehensive literature on its advances.In this review,the source,biotoxicity and detection methods are summarized.Among the sources is the material of chemical reaction,a metabolite of nitrofurazone,food processing(production by azobisformamide and hypochlorite treatment),endogenous substances,etc.Semicarbazide is demonstrated to be accumulative and reproductive toxicity,mutagenicity and genotoxicity,endocrine disruptors,and neurotoxicity.There are still many controversies on the effect of genotoxicity and no clear result on the carcinogenic mechanism.HPLC-MS/MS is the mainstream of the detection methods.Other methods,including HPLC,immunoassay method,biosensor method,electrochemical detection,capillary electrophoresis technique,and spectral techniques mainly,have become less and less in recent years.On all these counts,to reduce the content of semicarbazide in the environment,the key is to control the use of nitrofurazone as the banned drug effectively.Meanwhile the toxicity data should be supplemented to reveal its toxic mechanism.

关 键 词：SEMICARBAZIDE POLLUTANT SOURCE TOXICITY detection methods 

分 类 号：X502[环境科学与工程—环境工程]