DACT2、PITX2在结肠癌、腺瘤组织中的表达及意义  

The expression and significance of DACT2 and PITX2 in colon cancer and colon adenoma tissues

作　　者：牛昊书[1] 陈吉[1] 侯羽菲 NIU Haoshu;CHEN Ji;HOU Yufei(Department of Gastroenterology,Inner Mongolia Baogang Hospital,Baotou 014010;Department of Gastroenterology,Qingdao West Coast People’s Hospital,China)

机构地区：[1]内蒙古包钢医院消化内科,内蒙古包头014010 [2]青岛西海岸区人民医院消化内科

出　　处：《胃肠病学和肝病学杂志》2021年第7期789-792,共4页Chinese Journal of Gastroenterology and Hepatology

摘　　要：目的检测DACT2和PITX2基因在正常结肠黏膜、结肠腺瘤及结肠癌组织中的表达水平,探讨二者在结肠癌发生、进展中的作用及其相互关系。方法采用qRT-PCR法检测DACT2和PITX2在不同结肠组织中的表达水平。结果DACT2在三组中的表达呈逐渐下降趋势,差异有统计学意义(P<0.001),PITX2表达在三组中呈逐渐上升趋势,差异有统计学意义(P<0.001),DACT2与PITX2在三组中的表达均呈负相关。结论DACT2在结肠癌进展过程中可能发挥抑癌基因的作用,PITX2在结肠腺瘤-结肠癌过程中可能起到促进其发展的作用,二者之间的相互作用可能在结肠黏膜癌变过程中起到一定作用,联合检测可能为提高结肠癌早期诊断率及后续的治疗拓展了新思路。Objective To detect the expression levels of DACT2 and PITX2 genes in normal colon mucosa,colon adenoma and colon cancer tissues,and to explore their roles in the occurrence and progression of colon cancer and their relationship.Methods qRT-PCR method was used to detect the expression levels of DACT2 and PITX2 in different colon tissues.Results The expression of DACT2 in the three groups was significantly different(P<0.001),showing a gradual downward trend,and the expression of PITX2 was gradually increasing in the three groups,and the difference was significant(P<0.001).The expression of DACT2 and PITX2 in the three groups were negatively correlated.Conclusion DACT2 may play a role in tumor suppressor genes during the progression of colon cancer,PITX2 may play a role in promoting its occurrence in the process of colon adenoma-colon cancer,and the interaction between the two may play a role in the process of colon cancer.To a certain extent,joint detection may expand new ideas for improving the early diagnosis rate of colon cancer and subsequent treatment.

关 键 词：DACT2 PITX2 结肠腺瘤 结肠癌 

分 类 号：R735.3[医药卫生—肿瘤]