发酵法生产L-岩藻糖的研究进展  

Research progress on the production of L-fucose by fermentation

作　　者：马巍 邹祥[1] MA Wei;ZOU Xiang(College of Pharmaceutical Sciences,Southwest University,Chongqing 400715,China)

机构地区：[1]西南大学药学院,重庆400715

出　　处：《食品与发酵工业》2021年第16期308-312,共5页Food and Fermentation Industries

摘　　要：L-岩藻糖(L-fucose)是一种具有免疫调节、抗感染、抗肿瘤等多种重要生理功能的稀有单糖。L-岩藻糖的生产方法主要有植物提取法、化学合成法和微生物发酵法,微生物发酵法具有生产周期短、产量高等优点,通过富含岩藻糖的胞外多糖生产L-岩藻糖是一种有效的方式。该文就发酵法生产L-岩藻糖的发酵工艺、代谢工程改造以及提取工艺等方面进行综述,并对未来发展方向提出展望。L-Fucose is a rare monosaccharide with many important physiological functions,such as immune regulation,anti-infection and anti-tumor.The production of L-fucose mainly include plant extraction,chemical synthesis,and microbial fermentation,in which mi-crobial fermentation has some advantages including effective productivity,high yield,and environmentally friendly.The hydrolysis of L-fu-cose from fucose-rich extracellular polysaccharide was an alternative process for L-fucose production.In this review,the fermentation process,metabolic engineering and extraction process of L-fucose produced by fermentation methods are discussed.

关 键 词：L-岩藻糖 菌种选育 发酵优化 代谢工程 分离纯化 

分 类 号：TQ929[轻工技术与工程—发酵工程]