釉基质蛋白衍生物对牙周组织再生相关细胞的生物学作用及其成血管作用的研究进展  

Biological and angiogenic effects of enamel matrix derivative on periodontal regeneration-related cells

作　　者：庄齐翔 董家辰[1] 束蓉[1] CHUANG Chi-hsiang;DONG Jia-chen;SHU Rong(Department of Periodontology,Shanghai Ninth People's Hospital,Shanghai Jiao Tong University School of Medicine,College of Stomatology,Shanghai Jiao Tong University,National Center for Stomatology,National Clinical Research Center for Oral Diseases,Shanghai Key Laboratory of Stomatology,Shanghai 200011,China)

机构地区：[1]上海交通大学医学院附属第九人民医院牙周病科,上海交通大学口腔医学院,国家口腔医学中心,国家口腔疾病临床医学研究中心,上海市口腔医学重点实验室,上海200011

出　　处：《上海交通大学学报（医学版）》2021年第8期1099-1102,共4页Journal of Shanghai Jiao tong University:Medical Science

基　　金：国家自然科学基金(81570977);上海市科学技术委员会资助项目(18ZR1422400)。

摘　　要：釉基质蛋白经研究证实能促进牙周组织再生,随后其被开发成釉基质蛋白衍生物(enamel matrix derivative,EMD)。目前在临床上,EMD已应用20余年,多项临床研究表示其亦具有较突出的牙周组织再生功能。血管生成是组织再生的关键步骤,即新生血管可将多种细胞因子运送到组织缺损区,以促进组织再生。同时,另有文献指出,EMD有成血管作用。该文就EMD对牙周组织再生相关细胞的作用及其成血管作用进行综述。Enamel matrix protein has been proved to promote periodontal regeneration,and later developed into enamel matrix derivative(EMD).At present,EMD has been used in clinic for more than 20 years,and a number of clinical studies have shown that it also has a prominent role in periodontal regeneration.Angiogenesis also plays an essential role in tissue regeneration.This process allows the transportation of numerous cytokines to tissue defect areas via newly formed blood vessel,which can then stimulate periodontal regeneration.Several researches have indicated that EMD can stimulate angiogenesis.In this paper,the effects of EMD on periodontal regeneration-related cells and angiogenesis are reviewed.

关 键 词：釉基质蛋白衍生物 血管生成 血管内皮细胞 牙周组织再生 

分 类 号：R781.42[医药卫生—口腔医学]