三联疗法联合生长抑素对Hp阳性消化性溃疡合并上消化道出血的临床疗效及对炎性因子的影响研究  

Study on the Clinical Effect of Triple Therapy combined with Somatostatin on Hp-positive Peptic Ulcer with Upper Gastrointestinal Bleeding and Its Influence on Inflammatory Factors

作　　者：许文君 XU Wenjun(Zoucheng People's Hospital of Jining City,Jining 273500,China)

机构地区：[1]山东省济宁市邹城市人民医院,山东邹城273500

出　　处：《中国医药指南》2021年第23期4-6,共3页Guide of China Medicine

摘　　要：目的探讨三联疗法联合生长抑素对Hp阳性消化性溃疡合并上消化道出血的临床疗效及对炎性因子的影响。方法本次纳入56例Hp阳性消化性溃疡合并上消化道出血患者,纳入时间2020年1~12月。患者个人资料、家庭信息均记录电子表格,采用随机数表法方式分两组:对照组28例、试验组28例。对照组:实施三联疗法,即:给予患者奥美拉唑肠溶片、胶体果胶铋胶囊、阿莫西林肠溶片,每日在早饭与晚饭后服用1次,每次0.9 mg,共治疗4周。试验组实施三联疗法联合生长抑素治疗,即:三联疗法与对照组一致;给予患者生长抑素,微量泵注250μg/h,持续注射72 h。观察两组临床疗效,观察两组凝血功能指标,包括血小板计数(PLT)、凝血酶原时间(PT)、凝血酶时间(TT),采集患者空腹静脉血液4 mL,使用血液分析仪进行检测。观察两组炎性因子指标,包括超敏C-反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6),同样采集患者空腹静脉血液4 mL,使用酶联免疫吸附法与放射免疫法检测。结果治疗后,试验组总有效率为96.43%(27/28),对照组总有效率为71.43%(20/28),试验组临床疗效要高于对照组,χ^(2)=6.486,P<0.05。治疗前,两组凝血功能指标对比并无差异,P>0.05;治疗后,试验组PLT指标高于对照组,PT、TT指标均低于对照组,P<0.05。治疗前,两组炎性因子指标对比并无差异,P>0.05;治疗后,试验组指标均低于对照组,P<0.05。结论三联疗法结合生长抑素在该患者中有着显著治疗价值,可有效控制患者出血量,减轻患者炎性症状,促进患者疾病康复。Objective To investigate the clinical effect of triple therapy combined with somatostatin on Hp-positive peptic ulcer combined with upper gastrointestinal bleeding and its influence on inflammatory factors.Methods A total of 56 cases of Hp-positive peptic ulcer patients with upper gastrointestinal bleeding were enrolled this time,and the enrollment period was from January 2020 to December 2020.The personal data and family information of the patients were recorded in electronic forms,and they were divided into two groups by random number table method:28 cases in the control group and 28 cases in the experimental group.Control group:triple therapy,namely:omeprazole enteric-coated tablets,colloidal pectin bismuth capsules,amoxicillin enteric-coated tablets,taken once a day after breakfast and dinner,each time 0.9 mg,for a total of 4 treatments week.The experimental group was given triple therapy combined with somatostatin therapy,that is:triple therapy was consistent with the control group;somatostatin was given to the patient with a micro-pump injection of 250μg/h for 72 hours.Observe the clinical efficacy of the two groups,observe the coagulation function indexes of the two groups,including platelet count(PLT),prothrombin time(PT),and thrombin time(TT).Collect 4 mL of fasting venous blood from the patient and use a blood analyzer for testing.Observe two groups of inflammatory factors,including high-sensitivity C-reactive protein(hs-CRP),tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),and collect 4 mL of fasting venous blood from the patient.Using enzyme-linked immunosorbent assay and radioimmunoassay.Results After treatment,the total effective rate of the experimental group was 27(96.43%),and the total effective rate of the control group was 20(71.43%).The clinical efficacy of the experimental group was higher than that of the control group,χ^(2)=6.486,P<0.05.Before treatment,there was no difference in the comparison of coagulation function indexes between the two groups,P>0.05;after treatment,the PLT index

关 键 词：消化性溃疡 上消化道出血 三联疗法 生长抑素 HP阳性 临床疗效 炎性因子 

分 类 号：R573.1[医药卫生—消化系统] R573.2[医药卫生—内科学]