血栓通联合硫酸氯吡格雷对进展性缺血性脑卒中患者神经功能与氧化应激的影响研究  

Study on the Effect of Xueshuantong Combined with Clopidogrel Sulfate on Neurological Function and Oxidative Stress in Patients with Progressive Ischemic Stroke

作　　者：杨珂 YANG Ke(Department of Neurology,Wenshang County People's Hospital,Jining 272501,China)

机构地区：[1]汶上县人民医院神经内科,山东济宁272501

出　　处：《中国医药指南》2021年第23期16-18,共3页Guide of China Medicine

摘　　要：目的探讨血栓通联合硫酸氯吡格雷对进展性缺血性脑卒中患者神经功能与氧化应激的影响。方法本研究以我院于2018年12月至2020年12月收治的200例进展性缺血性脑卒中患者作为研究对象,将其随机分为100例试验组和100例对照组。对照组与试验组都进行常规治疗,如改善微循环、调血脂等。对照组在此基础上,以2周为1个疗程,采取口服硫酸氯吡格雷治疗的方式。观察组在对照组的基础上联合血栓通注射液治疗,以2周为1个疗程。观察并比较两组患者的氧化应激指标、神经功能评分以及血清学指标等方面的情况。结果治疗开始前,试验组和对照组患者的MDA、SOD水平没有明显差异(P>0.05),治疗结束后,MDA、SOD水平比治疗之前高,并且试验组的MDA、SOD的水平高于对照组(P<0.05)。治疗开始前,试验组和对照组患者的MMSE、NIHSS评分没有明显差异(P>0.05)。治疗结束后,两组MMSE评分高于治疗之前的评分,且试验组的MMSE评分高于对照组;两组NIHSS评分低于治疗之前的评分,且试验组的NIHSS评分低于对照组(P<0.05)。治疗开始前,试验组和对照组患者的TNF-α、Hcy水平比较没有明显差异(P>0.05)。治疗结束后,两组的TNF-α、Hcy水平低于治疗之前,并且试验组的TNF-α、Hcy水平低于对照组(P<0.05)。结论血栓通注射液联合硫酸氯吡格雷对进展性缺血性脑卒中患者神经功能及氧化应激的影响,具有一定临床价值,值得在临床上加以广泛推广以及应用。Objective To investigate the effect of xueshuantong combined with clopidogrel sulfate on neurological function and oxidative stress in patients with progressive ischemic stroke.Methods In this study,200 patients with progressive ischemic stroke admitted to our hospital from December 2018 to December 2020 were taken as the research objects,and they were randomly divided into 100 patients experimental groups and 100 patients control groups.Both the control group and the experimental group received conventional treatments,such as improving microcirculation and regulating blood lipids.On this basis,the control group took oral clopidogrel sulfate treatment with 2 weeks as a course of treatment.The observation group was combined with xueshuantong injection on the basis of the control group,with 2 weeks as a course of treatment.Observe and compare the oxidative stress indicators,neurological function scores and serological indicators of the two groups of patients.Results Before the start of treatment,there was no significant difference between the MDA and SOD levels of the experimental group and the control group(P>0.05).After the treatment,the MDA and SOD levels were higher than before the treatment,and the MDA and SOD levels of the experimental group were higher than the control group(P<0.05).Before treatment,the MMSE and NIHSS scores of the experimental group and the control group were no significantly different(P>0.05).After treatment,the MMSE scores of the two groups were higher than the scores before treatment,and the MMSE scores of the experimental group were higher than those of the control group;the NIHSS scores of the two groups were lower than the scores before treatment,and the NIHSS scores of the experimental group were lower than those of the control group,(P<0.05).Before treatment,there was no significant difference in the levels of TNF-αand Hcy between the experimental group and the control group(P>0.05).After treatment,the levels of TNF-αand Hcy in the two groups were lower than before treatment,and t

关 键 词：进展性缺血性脑卒中 血栓通 硫酸氯吡格雷 神经功能 氧化应激 

分 类 号：R743.3[医药卫生—神经病学与精神病学]