三联疗法和传统方案治疗NVG的疗效对比  

Comparison of Efficacy Between Triple Therapy and Conventional Therapy for NVG

作　　者：钱钰鑫 安刚[2] Qian Yuxin;An Gang(Graduate School,Jinzhou Medical University;Department of Ophthalmology,Jinzhou Central Hospital,Jinzhou 121000 China)

机构地区：[1]锦州医科大学研究生学院 [2]锦州市中心医院眼科,辽宁锦州121000

出　　处：《锦州医科大学学报》2021年第4期44-47,共4页Journal of Jinzhou Medical University

基　　金：辽宁省“百千万人才工程”,项目编号:辽百千万立项【2017】10号。

摘　　要：目的探讨球内注射康柏西普及Ahmed引流阀植入术联合全视网膜光凝术(panretinal photocoagulation,PRP)三联疗法和传统方案单纯睫状体光凝术(transscleral ciliary photocoagulation,TCP)联合全视网膜光凝术治疗新生血管性青光眼(neocascular-glaucoma,NVG)的临床疗效对比。方法将2018年10月至2021年2月于锦州市中心医院明确诊断为新生血管性青光眼的患者48例48眼,按照随机数字抽签法分为试验组26例26眼,对照组22例22眼。试验组行三联治疗玻璃体腔内注射康柏西普、Ahmed引流阀植入术联合全视网膜光凝,对照组行传统疗法单纯睫状体光凝术联合全视网膜光凝。比较两组患者手术前及术后6个月眼压、视力及并发症情况。结果术后6个月,两组眼压较治疗前均降低,且试验组眼压(12.58±3.41)mmHg低于对照组(17.32±3.29)mmHg(P<0.05)。试验组视力保留及提高情况明显优于对照组。试验组术后并发症发生率为7.70%,对照组为31.82%。结论三联疗法相较于传统方案睫状体光凝术联合全视网膜光凝术治疗新生血管性青光眼更能有效的控制患者眼压,保留现有视功能,降低并发症风险,可作为NVG患者首选治疗方案。Objective To compare the efficacy between triple therapy,namely intraocular injection of conbercept and Ahmed drainage valve implantation combined with panretinal photocoagulation(PRP),and conventional therapy,namely transscleral ciliary photocoagulation(TCP)combined with panretinal photocoagulation,in the treatment of neovascular glaucoma(NVG).Methods A total of 48 eyes of 48 patients with neovascular glaucoma diagnosed in Jinzhou Central Hospital from October 2018 to February 2021 were randomly divided into experimental group(n=26)and control group(n=22).The experimental group received triple therapy which was intravitreal injection of conbercept and Ahmed drainage valve implantation combined with panretinal photocoagulation,while the control group was treated with conventional therapy which was transscleral ciliary photocoagulation combined with panretinal photocoagulation.The intraocular pressure,visual acuity and complications before and 6 months after operation were compared between the two groups.Results The intraocular pressure 6 months after operation in both groups was lower that before operation.The intraocular pressure in the experimental group was(12.58±3.41)mmHg,lower than that in the control group which was(17.32±3.29)mmHg(P<0.05).The retention and improvement of visual acuity in the experimental group were better than those in the control group.The incidence of postoperative complications was 7.70%in the experimental group and 31.82%in the control group.Conclusion Compared with conventional therapy,namely ciliary photocoagulation,triple therapy can more effectively control patients intraocular pressure,retain the existing visual function and reduce the risk of complications in the treatment of neovascular glaucoma,which makes it the preferred treatment for NVG.

关 键 词：新生血管性青光眼 康柏西普 Ahmed引流阀植入术 全视网膜光凝 

分 类 号：R775[医药卫生—眼科]