脑缺血动物模型的制备及评估进展  

Construction and Evaluation of Animal Models for Cerebral Ischemia

作　　者：胡志斌 黄缨 丁玉强 HU Zhibin;HUANG Ying;DING Yuqiang(Department of Laboratory Animal Science,Fudan University,Shanghai 200032,China;Institutes of Brain Science,Fudan University,Shanghai 200032,China)

机构地区：[1]复旦大学实验动物科学部,上海200032 [2]复旦大学脑科学研究院,上海200032

出　　处：《实验动物与比较医学》2021年第4期271-283,共13页Laboratory Animal and Comparative Medicine

基　　金：上海市科学技术委员会科研项目(19490714300);上海市卫生健康委协同创新集群计划项目(2020CXJQ01)。

摘　　要：脑缺血是临床上常见的脑血管疾病,约占所有脑血管疾病的80%,其主要是由于脑血管供血不足引起。目前已有多种动物模型被用来进行脑缺血致病机制及治疗研究。本文结合造模示意图,介绍全脑及局灶性相关脑缺血动物模型的种类及制备方法,并对其优缺点进行了概括;同时对脑缺血模型制备所用的动物种类、啮齿类动物相关感觉运动能力评估及组织学评估的研究进展进行综述,以期为脑缺血动物模型的选择和应用提供参考。Cerebral ischemia is a common clinical cerebrovascular disease,accounting for about 80%of all cerebrovascular diseases,and it is mainly caused by insufficient blood supply to the cerebrovascular system.Multiple animal models have currently been used to study the pathogenesis and treatment of cerebral ischemia.In order to provide a reference for the selection and improvement of animal models for exploration of underlying mechanisms,this review highlights multiple animal models on global and focal cerebral ischemia with diagrams,and discusses their advantages and disadvantages.The choice of animals,behavioral evaluations of rodent sensory-motor activities,and histological evaluation progress for cerebral ischemia models are also outlined.

关 键 词：脑缺血 动物模型 感觉运动行为 

分 类 号：Q95-33[生物学—动物学] R-332[医药卫生]