长链非编码RNA MALAT1在肿瘤诊治中的研究进展  

Advances of long non⁃coding RNA MALAT1 in diagnosis and treatment of tumors

作　　者：李悄 李国政 张博[3] 王伟[1] LI Qiao;LI Guozheng;ZHANG Bo;WANG Wei(Department of Bacteriology and Immunology,Beijing Chest Hospital,Capital Medical University,Beijing Tuberculosis and Thoracic Tumor Research Institute,Beijing 101149,China;不详)

机构地区：[1]首都医科大学附属北京胸科医院,北京市结核病胸部肿瘤研究所耐药结核病研究北京市重点实验室细菌免疫室,北京101149 [2]安徽医科大学生命科学学院遗传学教研室,合肥230032 [3]安徽医科大学第二附属医院肿瘤科,合肥230601

出　　处：《实用医学杂志》2021年第16期2164-2167,共4页The Journal of Practical Medicine

基　　金：北京市科技重大专项(编号:D181100000418004)。

摘　　要：长链非编码RNA(long non⁃coding RNA,lncRNAs)是一种长度大于200 nt且不具备编码潜能的转录本,因其异常表达与肿瘤的发生、发展密切相关而成为当前的研究热点。MALAT1作为最早发现的lncRNA之一,可通过不同途径参与调控肿瘤细胞的增殖、凋亡、侵袭以及转移等,影响肿瘤的发展进程。本文即针对MALAT1在多种肿瘤中的研究现状做一综述,为今后肿瘤的诊断和治疗提供新思路。Long non⁃coding RNA(lncRNA)is a kind of non⁃coding transcripts longer than 200nt.Abnormal expression of lncRNAs is associated with various types of tumors.MALAT1,one of the first lncRNAs to be discov⁃ered,can regulate the proliferation,apoptosis,metastasis and invasion of tumor cells through different pathways and affect the progression of tumors.The present study reviews the current status of MALAT1 in many kinds of tumors,and provides a novel perspective on the diagnosis and treatment of tumors.

关 键 词：MALAT1 lncRNA 肿瘤 诊断 治疗靶点 

分 类 号：R730[医药卫生—肿瘤]