血清尿酸水平与急性特发性炎性脱髓鞘疾病的相关性研究  

Correlation between serum uric acid level and acute idiopathic inflammatory demyelinating disease

作　　者：于菲 张潇 张枭航 王子田 李婉婷[1] 刘丽波[1] 王哲[1] YU Fei;ZHANG Xiao;ZHANG Xiaohang(Department of Neurology,First Affiliated Hospital of Dalian Medical University,Dalian 116011,China)

机构地区：[1]大连医科大学附属第一医院神经内科,辽宁大连116011 [2]天津环湖医院,天津300350

出　　处：《中风与神经疾病杂志》2021年第7期629-632,共4页Journal of Apoplexy and Nervous Diseases

摘　　要：目的探讨特发性炎性脱髓鞘疾病患者急性期血清中UA表达水平与疾病活动的相关性。方法分别检测观察组(40例观察MS组患者,27例观察NMO组患者)及67例对照组人群血清中UA表达水平,比较观察组与对照组UA的表达差异;同时分析研究者血清中的UA水平与性别、发病年龄、EDSS评分之间的关系。结果(1)观察组MS及NMO患者血清中UA水平均较对照组低;(2)观察组男性MS患者UA水平高于女性,差异均有统计学意义(P<0.05);观察组NMO患者男女间UA值差异无统计学意义(P>0.05);(3)观察组MS及NMO患者UA值、发病年龄及EDSS评分之间均无相关性(P>0.05)。结论血清UA的改变在MS及NMO的病情活动及病理损伤过程中均发挥着重要作用;性别对UA在MS及的发病过程中的调节有一定的影响;MS及NMO患者血清UA的水平与年龄及EDSS评分无关。Objective To explore the correlation between serum UA expression levels and disease activity in patients with idiopathic inflammatory demyelinating disease.Methods To test serum UA level of the observation group(40 MS patients in observation group,27 NMO patients in observation group)and 67 controls,compare the difference of UA expression between observation group and control group;The relationship between serum UA level and sex,age of onset and EDSS score was also analyzed.Results(1)The serum UA expression levels in the MS and NMO group was lower than that in the control group;(2)The UA level of male MS patients in the observation group was higher than that of women,all differences were statistically significant(P<0.05);There was no significant difference in UA between men and women in the observation group(P>0.05);(3)There was no correlation between UA value,onset age and EDSS score of MS and NMO patients in observation group(P>0.05).Conclusions The changes of serum UA play an important role in MS and NMO disease activity and pathological injury;Sex has certain influence on the regulation of ua in MS and pathogenesis;The level of serum UA in MS and NMO patients was not related to age and EDSS score.

关 键 词：多发性硬化 视神经脊髓炎 尿酸 

分 类 号：R744.5[医药卫生—神经病学与精神病学]