Mesenchymal stem cells for treatment of steroid-resistant acute rejection after liver transplantation  

作　　者：Yingcai Zhang Shihui Li Guoying Wang Yanwen Peng Qi Zhang Hua Li Jian Zhang Genshu Wang Shuhong Yi Xiaoyong Chen Andy Peng Xiang Yang Yang Guihua Chen 

机构地区：[1]Department of Hepatic Surgery,Liver Transplantation Center,The Third Affiliated Hospital of Sun Yat-sen University,Organ Transplantation Institute,Sun Yat-sen University,Organ Transplantation Research Center of Guangdong Province,Guangzhou,China [2]Cell-Gene Therapy Translational Medicine Research Center,The Third Affiliated Hospital of Sun Yat-sen University,Guangzhou,China [3]Center for Stem Cell Biology and Tissue Engineering,Key Laboratory for Stem Cells and Tissue Engineering,Ministry of Education,Sun Yat-sen University,Guangzhou,China

出　　处：《Liver Research》2017年第2期140-145,共6页肝脏研究（英文）

基　　金：This work was supported by the grants from the National Natural Science Foundation of China(No.81370575,81570593);Guangdong Natural Science Foundation(2015A030312013),Scitech Research Development Program of Guangdong province(2017A020215023);Sci-tech Research Development Program of Guangzhou city(No.158100076,201400000001-3);Sun Yat-sen University Clinical Research 5010 Program(2014006);Young teacher development program of Sun Yat-sen University(17ykpy57).

摘　　要：A patient with steroid-resistant acute rejection 50 days after ABO-compatible orthotopic liver transplantation(LT)received regular infusion of allogeneic mesenchymal stem cells(MSCs)after three sessions of steroid pulse therapy which failed to control the pathogenetic condition as shown by biopsy.Liver function improved gradually after intravenous injection of MSCs once weekly for 10 weeks(as confirmed by biopsy)and remained stable under administration of conventional immunosuppressive agents.There was no evidence of neoplasms 5 years after treatment.MSCs infusion appears to successfully reverse resistance to immunosuppressive agents and may be a useful treatment for post-liver transplant steroid-resistant rejection.

关 键 词：Mesenchymal stem cells(MSCs) Liver transplantation(LT) Steroid-resistant acute rejection IMMUNOREGULATION 

分 类 号：R32[医药卫生—人体解剖和组织胚胎学]