粤西地区96例左旋多巴诱发异动症的帕金森病发病年龄特点分析  

Age characteristics of 96 Parkinson's disease patients with levodopa-induced dyskinesis in western Guangdong

作　　者：林智君 郑冼华[2] 王萍 刘洲 Lin Zhijun;Zheng Xianhua;Wang Ping;Liu Zhou(Department of Neurology,Affiliated Hospital of Guangdong Medical University,Zhanjiang 524023,China;Maternal and Child Health Hospital of Guangdong Province,Guangzhou 510010,China;Lingnan Normal University,Zhanjiang 524048,China)

机构地区：[1]广东医科大学附属医院神经内科,湛江524023 [2]广东省妇幼保健院,广州510010 [3]岭南师范学院,湛江524048

出　　处：《国际医药卫生导报》2021年第15期2233-2236,共4页International Medicine and Health Guidance News

基　　金：国家自然科学基金项目(81400986);广东省社科规划项目基金项目(GD19CTY10);湛江市非资助科技攻关项目(2021B01044)。

摘　　要：目的分析粤西地区左旋多巴诱发异动症(LID)的帕金森病发病年龄特点及其机制探讨。方法选取广东医科大学附属医院2015年10月至2021年1月期间收治的625例帕金森病患者,其中发生LID 96例,通过调查异动症患者的性别、年龄、发病年龄、服用左旋多巴的剂量、用药时间情况,以及比较不同年龄段、不同服药年限的帕金森患者发生异动症的年龄特点,并进行统计学数据分析。结果发生LID 96例(异动组),男性45例,女性51例,年龄(57.0±9.0)岁;非异动组529例,男性269例,女性260例,年龄(61.8±10.4)岁;两组性别比较差异无统计学意义(P>0.05),年龄比较差异有统计学意义(P<0.05)。异动组左旋多巴用药剂量为(416.7±217.4)mg/d、治疗时间为(5.6±2.9)年,非异动组分别为(383.6±199.0)mg/d、(4.7±2.2)年,差异均有统计学意义(均P<0.05)。LID的发生率与帕金森病的发病年龄显著相关(P<0.001),65岁以下患者左旋多巴治疗前3年LID发生率最高,第5年后最低(P=0.001);而对于66岁以上PD患者,第3~5年内LID的发生率最高(P=0.035)。结论帕金森病发病年龄是LID的主要因素,因此帕金森发病年龄可作为治疗帕金森病左旋多巴用药一个重要的参考因素。Objective To analyze the age characteristics and mechanism of Parkinson's disease patients with levodopa-induced dyskinesis(LID)in western Guangdong.Methods From October 2015 to January 2021,625 patients with Parkinson's disease who were admitted to Affiliated Hospital of Guangdong Medical University were selected.Among which,96 patients had LID.The 96 patients'gender,onset age,dosage of levodopa,and medication duration were investigated.The age characteristics of the patients of different ages and years of medication were compared,and the data were statistically analyzed.Results Among the LID patients,there were 45 males and 51 females,and they were(57.0±9.0)years old;among the 529 non-LID patients,there were 269 males and 260 females,and they were(61.8±10.4)years old;there was no statistical difference in gender between the two groups(P>0.05),and was in age(P<0.05).The dosage of levodopa and the medication duration were(416.7±217.4)mg/d and(5.6±2.9)years in the LID patients,and were(383.6±199.0)mg/d and(4.7±2.2)years in the non-LID patients(both P<0.05).The incidence of LID was significantly correlated with the onset age of Parkinson's disease(P<0.001).The incidence of LID in the patients under 65 years old was the highest within 3 years after levodopa treatment,and was the lowest 5 years after the treatment(P=0.001).For≥66 years old PD patients,the incidence of LID was the highest 3-5 years after levodopa treatment(P=0.035).Conclusions The onset age of Parkinson's disease is the main factor of LID.Therefore,the onset age of Parkinson's disease may be an important reference factor for the levodopa treatment of Parkinson's disease.

关 键 词：帕金森病 左旋多巴诱导异动症 发病年龄 

分 类 号：R742.5[医药卫生—神经病学与精神病学]